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- W2080889507 abstract "The factor V Leiden polymorphism or deficiencies of proteins intimately linked with thrombin regulation, such as protein C and protein S, are well-characterised risk factors for venous thrombosis. In 1996, Weiss et al reported that a platelet-surface polymorphism was associated with a twofold increase in the risk of coronary ischaemia. 1 Weiss ET Bray PF Tayback M et al. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N. Engl J Med. 1996; 334: 1090-1094 Crossref PubMed Scopus (695) Google Scholar The aminoacid change in question was not new, being a substitution of proline for leucine-33 in glycoprotein (GP) IIIa. 2 Kunicki TJ Newman PJ The molecular biology of human platelet proteins. Blood. 1992; 80: 1396-1404 Google Scholar Giving rise to the HPA-1a/b (PIA1/A2) alloantigen system, this polymorphism underlies a high proportion of cases of post-transfusion purpura and neonatal alloimmune thrombocytopenia, where platelet incompatibility leads to alloantibody production and immune-related platelet destruction. HPA-1b is expressed on platelets of 24-28% of Caucasians (with about 2% of individuals homozygous for the alloantigen), but is virtually never seen in people from Far Eastern countries, such as Japan. Platelet glycoprotein Illa polymorphisms and risk of coronary stent thrombosisPatients with the PlA2 allele have an increased risk of coronary stent thrombosis, which may warrant antiplatelet therapy with glycoprotein-llb/Illa inhibitors, although bleeding complications may also increase. Full-Text PDF" @default.
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- W2080889507 date "1997-10-01" @default.
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- W2080889507 title "Platelet glycoprotein Illa polymorphism ane coronary thrombosis" @default.
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- W2080889507 doi "https://doi.org/10.1016/s0140-6736(05)63447-2" @default.
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