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- W2080898071 abstract "The impact of manipulating explicit attentional demands on working memory has not been well studied in rodents. The present experiment was designed to test the effects of incorporating a retention interval in a two-lever sustained attention task that requires discrimination of visual signals and non-signals and that has previously been shown to yield valid measures of attention in the rat. Upon establishing baseline performance, additional manipulations, including presentation of a visual distracter and increasing the length and variability of the inter-trial interval were conducted. During baseline conditions, accurate detection of signals, but not non-signals, decreased as the retention interval was increased. Presentation of a flashing houselight throughout the session eliminated delay-dependent detection of signals. Increasing the inter-trial interval improved detection of signals and decreased detection of non-signals at the longest retention interval. Finally, increasing the variability of the inter-trial interval did not have significant effects on performance above and beyond the effects of increasing the inter-trial interval. The present experiment demonstrates that manipulation of explicit attentional demands can alter working memory performance in the rat. This task may be employed to understand the neuropharmacological and neuroanatomical substrates mediating memory while attentional load is systematically varied." @default.
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- W2080898071 date "2004-11-01" @default.
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- W2080898071 title "Introduction of a retention interval in a sustained attention task in rats: effects of a visual distracter and increasing the inter-trial interval" @default.
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- W2080898071 doi "https://doi.org/10.1016/j.beproc.2004.08.009" @default.
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