Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080900207> ?p ?o ?g. }
- W2080900207 endingPage "236" @default.
- W2080900207 startingPage "230" @default.
- W2080900207 abstract "Tissue factor (TF), which is expressed in atherosclerotic plaques and colocalizes with oxidized lipids, initiates the thrombogenic process. We have analyzed the effect of aldehydes derived from peroxidation of polyunsaturated fatty acids on TF expression in human vascular smooth muscle cells (HVSMC). Our results demonstrate that hexanal and 2,4-decadienal (2,4-DDE), two apolar aldehydes, increase TF expression. Exposure of HVSMC to hexanal for 2 h led to TF protein levels up to seven times higher than untreated cells whereas 2,4-DDE for 30 min led to them being up to 2.2 times higher. This induction of TF antigen by aldehydes correlates with an increase in TF mRNA levels. Electrophoretic mobility shift assays (EMSAs) showed that the binding activity of the transcription factor AP-1 (c-Fos/c-Jun) to TF promoter was elevated in response to these oxidation products. This enhancement was associated to an increase of c-fos transcriptional activity, which was reversible by pretreatment with simvastatin. We conclude that the induction of TF by aldehydes might contribute to the severity of atherogenesis." @default.
- W2080900207 created "2016-06-24" @default.
- W2080900207 creator A5016780918 @default.
- W2080900207 creator A5037202658 @default.
- W2080900207 creator A5048724654 @default.
- W2080900207 creator A5057374991 @default.
- W2080900207 date "2003-10-28" @default.
- W2080900207 modified "2023-10-10" @default.
- W2080900207 title "Aldehydes mediate tissue factor induction: A possible mechanism linking lipid peroxidation to thrombotic events" @default.
- W2080900207 cites W1124883296 @default.
- W2080900207 cites W1485364676 @default.
- W2080900207 cites W1858039675 @default.
- W2080900207 cites W1934175771 @default.
- W2080900207 cites W1968671826 @default.
- W2080900207 cites W1983998081 @default.
- W2080900207 cites W1992803891 @default.
- W2080900207 cites W2016249400 @default.
- W2080900207 cites W2016892899 @default.
- W2080900207 cites W2022080130 @default.
- W2080900207 cites W2025624168 @default.
- W2080900207 cites W2027032244 @default.
- W2080900207 cites W2027717748 @default.
- W2080900207 cites W2029602474 @default.
- W2080900207 cites W2033881357 @default.
- W2080900207 cites W2053837324 @default.
- W2080900207 cites W2056732116 @default.
- W2080900207 cites W2063429313 @default.
- W2080900207 cites W2067034969 @default.
- W2080900207 cites W2071115174 @default.
- W2080900207 cites W2072608243 @default.
- W2080900207 cites W2078372594 @default.
- W2080900207 cites W2100391645 @default.
- W2080900207 cites W2110569594 @default.
- W2080900207 cites W2113771464 @default.
- W2080900207 cites W2139922949 @default.
- W2080900207 cites W2156255102 @default.
- W2080900207 cites W2159633079 @default.
- W2080900207 cites W2163268769 @default.
- W2080900207 cites W2745444616 @default.
- W2080900207 cites W4256475235 @default.
- W2080900207 cites W4293247451 @default.
- W2080900207 cites W969915667 @default.
- W2080900207 doi "https://doi.org/10.1002/jcp.10423" @default.
- W2080900207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14603525" @default.
- W2080900207 hasPublicationYear "2003" @default.
- W2080900207 type Work @default.
- W2080900207 sameAs 2080900207 @default.
- W2080900207 citedByCount "13" @default.
- W2080900207 countsByYear W20809002072013 @default.
- W2080900207 countsByYear W20809002072017 @default.
- W2080900207 countsByYear W20809002072018 @default.
- W2080900207 countsByYear W20809002072023 @default.
- W2080900207 crossrefType "journal-article" @default.
- W2080900207 hasAuthorship W2080900207A5016780918 @default.
- W2080900207 hasAuthorship W2080900207A5037202658 @default.
- W2080900207 hasAuthorship W2080900207A5048724654 @default.
- W2080900207 hasAuthorship W2080900207A5057374991 @default.
- W2080900207 hasConcept C104317684 @default.
- W2080900207 hasConcept C126322002 @default.
- W2080900207 hasConcept C153911025 @default.
- W2080900207 hasConcept C185592680 @default.
- W2080900207 hasConcept C186738567 @default.
- W2080900207 hasConcept C2776151105 @default.
- W2080900207 hasConcept C2778353584 @default.
- W2080900207 hasConcept C2778382381 @default.
- W2080900207 hasConcept C2780829032 @default.
- W2080900207 hasConcept C31903555 @default.
- W2080900207 hasConcept C55493867 @default.
- W2080900207 hasConcept C71924100 @default.
- W2080900207 hasConcept C86339819 @default.
- W2080900207 hasConcept C86803240 @default.
- W2080900207 hasConcept C95444343 @default.
- W2080900207 hasConceptScore W2080900207C104317684 @default.
- W2080900207 hasConceptScore W2080900207C126322002 @default.
- W2080900207 hasConceptScore W2080900207C153911025 @default.
- W2080900207 hasConceptScore W2080900207C185592680 @default.
- W2080900207 hasConceptScore W2080900207C186738567 @default.
- W2080900207 hasConceptScore W2080900207C2776151105 @default.
- W2080900207 hasConceptScore W2080900207C2778353584 @default.
- W2080900207 hasConceptScore W2080900207C2778382381 @default.
- W2080900207 hasConceptScore W2080900207C2780829032 @default.
- W2080900207 hasConceptScore W2080900207C31903555 @default.
- W2080900207 hasConceptScore W2080900207C55493867 @default.
- W2080900207 hasConceptScore W2080900207C71924100 @default.
- W2080900207 hasConceptScore W2080900207C86339819 @default.
- W2080900207 hasConceptScore W2080900207C86803240 @default.
- W2080900207 hasConceptScore W2080900207C95444343 @default.
- W2080900207 hasIssue "2" @default.
- W2080900207 hasLocation W20809002071 @default.
- W2080900207 hasLocation W20809002072 @default.
- W2080900207 hasOpenAccess W2080900207 @default.
- W2080900207 hasPrimaryLocation W20809002071 @default.
- W2080900207 hasRelatedWork W1516453490 @default.
- W2080900207 hasRelatedWork W2067310191 @default.
- W2080900207 hasRelatedWork W2135648199 @default.
- W2080900207 hasRelatedWork W2136457142 @default.
- W2080900207 hasRelatedWork W2209649329 @default.
- W2080900207 hasRelatedWork W244157645 @default.