FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080916219> ?p ?o ?g. }

• W2080916219 endingPage "e1000760" @default.
• W2080916219 startingPage "e1000760" @default.
• W2080916219 abstract "Fungal pathologies are seen in immunocompromised and healthy humans. C-type lectins expressed on immature dendritic cells (DC) recognize fungi. We report a novel dorsal pseudopodial protrusion, the fungipod, formed by DC after contact with yeast cell walls. These structures have a convoluted cell-proximal end and a smooth distal end. They persist for hours, exhibit noticeable growth and total 13.7+/-5.6 microm long and 1.8+/-0.67 microm wide at the contact. Fungipods contain clathrin and an actin core surrounded by a sheath of cortactin. The actin cytoskeleton, but not microtubules, is required for fungipod integrity and growth. An apparent rearward flow (225+/-55 nm/second) exists from the zymosan contact site into the distal fungipod. The phagocytic receptor Dectin-1 is not required for fungipod formation, but CD206 (Mannose Receptor) is the generative receptor for these protrusions. The human pathogen Candida parapsilosis induces DC fungipod formation strongly, but the response is species specific since the related fungal pathogens Candida tropicalis and Candida albicans induce very few and no fungipods, respectively. Our findings show that fungipods are dynamic actin-driven cellular structures involved in fungal recognition by DC. They may promote yeast particle phagocytosis by DC and are a specific response to large (i.e., 5 microm) particulate ligands. Our work also highlights the importance of this novel protrusive structure to innate immune recognition of medically significant Candida yeasts in a species specific fashion." @default.
• W2080916219 created "2016-06-24" @default.
• W2080916219 creator A5064846610 @default.
• W2080916219 creator A5084760187 @default.
• W2080916219 date "2010-02-12" @default.
• W2080916219 modified "2023-09-27" @default.
• W2080916219 title "A Novel Pseudopodial Component of the Dendritic Cell Anti-Fungal Response: The Fungipod" @default.
• W2080916219 cites W1519901358 @default.
• W2080916219 cites W1603724904 @default.
• W2080916219 cites W1965313627 @default.
• W2080916219 cites W1966487254 @default.
• W2080916219 cites W1973106646 @default.
• W2080916219 cites W1985048358 @default.
• W2080916219 cites W1988940275 @default.
• W2080916219 cites W1995441274 @default.
• W2080916219 cites W1996242613 @default.
• W2080916219 cites W1998331436 @default.
• W2080916219 cites W1998733027 @default.
• W2080916219 cites W1999340863 @default.
• W2080916219 cites W1999816397 @default.
• W2080916219 cites W2003252331 @default.
• W2080916219 cites W2009582035 @default.
• W2080916219 cites W2010781630 @default.
• W2080916219 cites W2020892139 @default.
• W2080916219 cites W2022331490 @default.
• W2080916219 cites W2024518999 @default.
• W2080916219 cites W2025957398 @default.
• W2080916219 cites W2026064166 @default.
• W2080916219 cites W2032432138 @default.
• W2080916219 cites W2038614099 @default.
• W2080916219 cites W2039325880 @default.
• W2080916219 cites W2041042935 @default.
• W2080916219 cites W2051410189 @default.
• W2080916219 cites W2054323226 @default.
• W2080916219 cites W2057760381 @default.
• W2080916219 cites W2073005565 @default.
• W2080916219 cites W2082390177 @default.
• W2080916219 cites W2096873347 @default.
• W2080916219 cites W2099241550 @default.
• W2080916219 cites W2099573412 @default.
• W2080916219 cites W2100080174 @default.
• W2080916219 cites W2101022277 @default.
• W2080916219 cites W2103147774 @default.
• W2080916219 cites W2108292732 @default.
• W2080916219 cites W2112659088 @default.
• W2080916219 cites W2112777571 @default.
• W2080916219 cites W2113280649 @default.
• W2080916219 cites W2114605201 @default.
• W2080916219 cites W2117411464 @default.
• W2080916219 cites W2124758037 @default.
• W2080916219 cites W2130941282 @default.
• W2080916219 cites W2132327341 @default.
• W2080916219 cites W2135628211 @default.
• W2080916219 cites W2138854186 @default.
• W2080916219 cites W2144011676 @default.
• W2080916219 cites W2150373017 @default.
• W2080916219 cites W2151397718 @default.
• W2080916219 cites W2151665495 @default.
• W2080916219 cites W2154068656 @default.
• W2080916219 cites W2155653297 @default.
• W2080916219 cites W2158288055 @default.
• W2080916219 cites W2160713438 @default.
• W2080916219 cites W2166070731 @default.
• W2080916219 cites W2171956751 @default.
• W2080916219 cites W2182298035 @default.
• W2080916219 cites W2360349223 @default.
• W2080916219 doi "https://doi.org/10.1371/journal.ppat.1000760" @default.
• W2080916219 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2820528" @default.
• W2080916219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20169183" @default.
• W2080916219 hasPublicationYear "2010" @default.
• W2080916219 type Work @default.
• W2080916219 sameAs 2080916219 @default.
• W2080916219 citedByCount "30" @default.
• W2080916219 countsByYear W20809162192012 @default.
• W2080916219 countsByYear W20809162192013 @default.
• W2080916219 countsByYear W20809162192014 @default.
• W2080916219 countsByYear W20809162192015 @default.
• W2080916219 countsByYear W20809162192017 @default.
• W2080916219 countsByYear W20809162192018 @default.
• W2080916219 countsByYear W20809162192019 @default.
• W2080916219 countsByYear W20809162192020 @default.
• W2080916219 countsByYear W20809162192021 @default.
• W2080916219 crossrefType "journal-article" @default.
• W2080916219 hasAuthorship W2080916219A5064846610 @default.
• W2080916219 hasAuthorship W2080916219A5084760187 @default.
• W2080916219 hasBestOaLocation W20809162191 @default.
• W2080916219 hasConcept C125705527 @default.
• W2080916219 hasConcept C136449434 @default.
• W2080916219 hasConcept C142669718 @default.
• W2080916219 hasConcept C1491633281 @default.
• W2080916219 hasConcept C160448771 @default.
• W2080916219 hasConcept C202751555 @default.
• W2080916219 hasConcept C203014093 @default.
• W2080916219 hasConcept C2776205754 @default.
• W2080916219 hasConcept C2778170410 @default.
• W2080916219 hasConcept C2779244956 @default.
• W2080916219 hasConcept C2780917455 @default.
• W2080916219 hasConcept C2993400109 @default.

• next