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• W2080924958 abstract "Research into the age-associated decline in the immune system has focused on the factors that contribute to the accumulation of senescent CD8 T cells. Less attention has been paid to the non-immune factors that may maintain the pool of naïve CD8 T cells. Here, we analyzed the status of the naïve CD8 T-cell population in healthy nonagenarians (≥90-year-old), old (60–79-year-old), and young (20–34-year-old) subjects. Naïve CD8 T cells were defined as CD28+CD95− as this phenotype showed a strong co-expression of the CD45RA+, CD45RO−, and CD127+ phenotypes. Although there was an age-associated decline in the percentage of CD28+CD95− CD8 T cells, the healthy nonagenarians maintained a pool of naïve CD28+CD95− cells that contained T-cell receptor excision circles (TREC)+ cells. The percentages of naïve CD28+CD95− CD8 T cells in the nonagenarians correlated with the sera levels of insulin-like growth factor binding protein 3 (IGFBP3) and leptin. Higher levels of triiodothyronine (T3) negatively correlated with the accumulation of TREC−CD28−CD95+ CD8 T cells from nonagenarians. These results suggest a model in which IGFBP3, leptin and T3 act as non-immune factors to maintain a larger pool of naïve CD8 T cells in healthy nonagenarians." @default.
• W2080924958 created "2016-06-24" @default.
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• W2080924958 date "2010-01-01" @default.
• W2080924958 modified "2023-10-18" @default.
• W2080924958 title "Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3" @default.
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• W2080924958 doi "https://doi.org/10.1016/j.mad.2009.11.003" @default.
• W2080924958 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2843505" @default.
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