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- W2080927073 abstract "Controversy exists regarding the management of spontaneous subclinical hypothyroidism, defined as a raised serum thyroid-stimulating hormone (TSH) but a normal serum thyroxine (T4) level in an asymptomatic patient. It is claimed that T4 therapy improves non-specific symptoms, prevents progression to overt hypothyroidism and reduces the cardiovascular risk by improving the atherogenic lipid profile. However, there are few data to suggest a positive benefit of T4 therapy in those documented to have a serum TSH between 5 and 10 mU l−1. Normalization of serum TSH with T4 is often not achieved in clinical practice, and detrimental effects on the skeleton, the cardiovascular system and even mortality have been suggested by subclinical hyperthyroidism, which can be a consequence of overtreatment with T4 therapy. Many patients will not progress to overt hypothyroidism in 20 years, and adopting a ‘wait and see’ policy rather than intervention will avoid unnecessary treatment and the potential for harm in a significant number of patients." @default.
- W2080927073 created "2016-06-24" @default.
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- W2080927073 date "2003-08-01" @default.
- W2080927073 modified "2023-10-02" @default.
- W2080927073 title "Subclinical hypothyroidism: the case against treatment" @default.
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- W2080927073 doi "https://doi.org/10.1016/s1043-2760(03)00103-6" @default.
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