FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080931187> ?p ?o ?g. }

• W2080931187 endingPage "4594" @default.
• W2080931187 startingPage "4586" @default.
• W2080931187 abstract "To explore the potential for use of ligand-conjugated nanocrystals to target cell surface receptors, ion channels, and transporters, we explored the ability of serotonin-labeled CdSe nanocrystals (SNACs) to interact with antidepressant-sensitive, human and Drosophila serotonin transporters (hSERT, dSERT) expressed in HeLa and HEK-293 cells. Unlike unconjugated nanocrystals, SNACs were found to dose-dependently inhibit transport of radiolabeled serotonin by hSERT and dSERT, with an estimated half-maximal activity (EC50) of 33 (dSERT) and 99 μM (hSERT). When serotonin was conjugated to the nanocrystal through a linker arm (LSNACs), the EC50 for hSERT was determined to be 115 μM. Electrophysiology measurements indicated that LSNACs did not elicit currents from the serotonin-3 (5HT3) receptor but did produce currents when exposed to the transporter, which are similar to those elicited by antagonists. Moreover, fluorescent LSNACs were found to label SERT-transfected cells but did not label either nontransfected cells or transfected cells coincubated with the high-affinity SERT antagonist paroxetine. These findings support further consideration of ligand-conjugated nanocrystals as versatile probes of membrane proteins in living cells." @default.
• W2080931187 created "2016-06-24" @default.
• W2080931187 creator A5000206544 @default.
• W2080931187 creator A5014592284 @default.
• W2080931187 creator A5022016058 @default.
• W2080931187 creator A5022425643 @default.
• W2080931187 creator A5024495651 @default.
• W2080931187 creator A5037493550 @default.
• W2080931187 creator A5049876115 @default.
• W2080931187 creator A5063744200 @default.
• W2080931187 creator A5072912533 @default.
• W2080931187 creator A5085507900 @default.
• W2080931187 date "2002-04-05" @default.
• W2080931187 modified "2023-09-27" @default.
• W2080931187 title "Targeting Cell Surface Receptors with Ligand-Conjugated Nanocrystals" @default.
• W2080931187 cites W1231310421 @default.
• W2080931187 cites W1511301017 @default.
• W2080931187 cites W1576505582 @default.
• W2080931187 cites W1642639203 @default.
• W2080931187 cites W1963499784 @default.
• W2080931187 cites W1987020425 @default.
• W2080931187 cites W2006842594 @default.
• W2080931187 cites W2010516521 @default.
• W2080931187 cites W2015068634 @default.
• W2080931187 cites W2020727025 @default.
• W2080931187 cites W2038980827 @default.
• W2080931187 cites W2039144704 @default.
• W2080931187 cites W2044543075 @default.
• W2080931187 cites W2050529989 @default.
• W2080931187 cites W2062485439 @default.
• W2080931187 cites W2080012080 @default.
• W2080931187 cites W2127846911 @default.
• W2080931187 cites W2152772915 @default.
• W2080931187 cites W2157238829 @default.
• W2080931187 cites W2160253297 @default.
• W2080931187 cites W2163694792 @default.
• W2080931187 cites W2166674578 @default.
• W2080931187 doi "https://doi.org/10.1021/ja003486s" @default.
• W2080931187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11971705" @default.
• W2080931187 hasPublicationYear "2002" @default.
• W2080931187 type Work @default.
• W2080931187 sameAs 2080931187 @default.
• W2080931187 citedByCount "335" @default.
• W2080931187 countsByYear W20809311872012 @default.
• W2080931187 countsByYear W20809311872013 @default.
• W2080931187 countsByYear W20809311872014 @default.
• W2080931187 countsByYear W20809311872015 @default.
• W2080931187 countsByYear W20809311872016 @default.
• W2080931187 countsByYear W20809311872017 @default.
• W2080931187 countsByYear W20809311872018 @default.
• W2080931187 countsByYear W20809311872019 @default.
• W2080931187 countsByYear W20809311872020 @default.
• W2080931187 countsByYear W20809311872021 @default.
• W2080931187 countsByYear W20809311872022 @default.
• W2080931187 countsByYear W20809311872023 @default.
• W2080931187 crossrefType "journal-article" @default.
• W2080931187 hasAuthorship W2080931187A5000206544 @default.
• W2080931187 hasAuthorship W2080931187A5014592284 @default.
• W2080931187 hasAuthorship W2080931187A5022016058 @default.
• W2080931187 hasAuthorship W2080931187A5022425643 @default.
• W2080931187 hasAuthorship W2080931187A5024495651 @default.
• W2080931187 hasAuthorship W2080931187A5037493550 @default.
• W2080931187 hasAuthorship W2080931187A5049876115 @default.
• W2080931187 hasAuthorship W2080931187A5063744200 @default.
• W2080931187 hasAuthorship W2080931187A5072912533 @default.
• W2080931187 hasAuthorship W2080931187A5085507900 @default.
• W2080931187 hasConcept C104317684 @default.
• W2080931187 hasConcept C111919701 @default.
• W2080931187 hasConcept C112613896 @default.
• W2080931187 hasConcept C116569031 @default.
• W2080931187 hasConcept C12554922 @default.
• W2080931187 hasConcept C1491633281 @default.
• W2080931187 hasConcept C170493617 @default.
• W2080931187 hasConcept C178790620 @default.
• W2080931187 hasConcept C185592680 @default.
• W2080931187 hasConcept C2775864247 @default.
• W2080931187 hasConcept C2777366897 @default.
• W2080931187 hasConcept C2778897192 @default.
• W2080931187 hasConcept C2780557392 @default.
• W2080931187 hasConcept C41008148 @default.
• W2080931187 hasConcept C521977710 @default.
• W2080931187 hasConcept C53910766 @default.
• W2080931187 hasConcept C54009773 @default.
• W2080931187 hasConcept C55493867 @default.
• W2080931187 hasConcept C86803240 @default.
• W2080931187 hasConceptScore W2080931187C104317684 @default.
• W2080931187 hasConceptScore W2080931187C111919701 @default.
• W2080931187 hasConceptScore W2080931187C112613896 @default.
• W2080931187 hasConceptScore W2080931187C116569031 @default.
• W2080931187 hasConceptScore W2080931187C12554922 @default.
• W2080931187 hasConceptScore W2080931187C1491633281 @default.
• W2080931187 hasConceptScore W2080931187C170493617 @default.
• W2080931187 hasConceptScore W2080931187C178790620 @default.
• W2080931187 hasConceptScore W2080931187C185592680 @default.
• W2080931187 hasConceptScore W2080931187C2775864247 @default.
• W2080931187 hasConceptScore W2080931187C2777366897 @default.
• W2080931187 hasConceptScore W2080931187C2778897192 @default.
• W2080931187 hasConceptScore W2080931187C2780557392 @default.

• next