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• W2080931237 abstract "In bacteria, the binding of a single protein, the initiation factor sigma, to a multi-subunit RNA polymerase core enzyme results in the formation of a holoenzyme, the active form of RNA polymerase essential for transcription initiation. Here we report the crystal structure of a bacterial RNA polymerase holoenzyme from Thermus thermophilus at 2.6 A resolution. In the structure, two amino-terminal domains of the sigma subunit form a V-shaped structure near the opening of the upstream DNA-binding channel of the active site cleft. The carboxy-terminal domain of sigma is near the outlet of the RNA-exit channel, about 57 A from the N-terminal domains. The extended linker domain forms a hairpin protruding into the active site cleft, then stretching through the RNA-exit channel to connect the N- and C-terminal domains. The holoenzyme structure provides insight into the structural organization of transcription intermediate complexes and into the mechanism of transcription initiation." @default.
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• W2080931237 date "2002-08-06" @default.
• W2080931237 modified "2023-09-27" @default.
• W2080931237 title "Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 Å resolution" @default.
• W2080931237 doi "https://doi.org/10.1107/s0108767302085318" @default.
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