FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080932789> ?p ?o ?g. }

• W2080932789 endingPage "67" @default.
• W2080932789 startingPage "46" @default.
• W2080932789 abstract "There are several lines of evidence that point to peptides participating in the regulation of LH and/or FSH levels by action at the pituitary. This evidence includes altered secretion of gonadotropins from the anterior pituitary cells or tissue in vitro when exposed to the peptide. Additionally, modification of GnRH-stimulated LH/FSH secretion has been observed. Furthermore, there is potential for a separately modulated interaction with the primed response. Another potential of action is by interaction among non-GnRH peptides on gonadotropin-regulating processes, although there are no good data available on this aspect. Other observations, consistent with a pituitary role for the peptides in modulation of LH, include detection of the peptides in portal blood, detection of high-affinity receptors or receptor mRNA in the pituitary, and detection of intrapituitary peptide or peptide mRNA in the pituitary. The modulation by steroids of both concentrations and type of activities provides a further level of physiological refinement. There is, however, some confusion regarding the involvement of these peptides in gonadotropin control. The reasons can be seen by considering aspects of investigations. There are experimental variations such as 1) species studied, e.g., NPY has been reported to have an effect on LH secretion from rat cells (168) but not on sheep anterior pituitary tissue (64), and substance P inhibits GnRH-stimulated release from rat cells (182) but potentiates the response in prepubertal porcine cells (92); 2) the steroidal conditions under which the study is performed, e.g., NPY has opposite effects in certain endocrine environments, augmenting GnRH-stimulated LH release in proestrus-like conditions (168), and inhibiting in metestrus-like environment (66); 3) the type of cell preparation, e.g., responsiveness to substance P might depend on whether cells in overnight culture were in separated or clustered state (91); 4) the time course considered, e.g., oxytocin that might induce marked LH release from pituitary cells after a longer length of incubation than GnRH requires (68); 5) length of exposure to peptide, e.g., endothelin that augmented or inhibited GnRH-stimulated LH release (50); 6) In addition, it is possible that the traditional endpoint selected in such studies, namely, observation of gonadotropin secretion, is not necessarily the most important for these peptides (56, 81, 117). Unfortunately, at this stage a definitive answer to the question What do the peptides actually do? cannot be provided and we remain tantalized by the glimpses of potential roles. Perhaps in a few years an updated review will be able to include a more complete answer. It is necessary for the full understanding of LH control that not only the properties of the peptides in isolation be characterized but also their interactions." @default.
• W2080932789 created "2016-06-24" @default.
• W2080932789 creator A5050390201 @default.
• W2080932789 date "1999-02-01" @default.
• W2080932789 modified "2023-10-18" @default.
• W2080932789 title "Modulation of Gonadotropin Levels by Peptides Acting at the Anterior Pituitary Gland" @default.
• W2080932789 cites W1494137510 @default.
• W2080932789 cites W1549118234 @default.
• W2080932789 cites W1583566762 @default.
• W2080932789 cites W1585981117 @default.
• W2080932789 cites W1586407696 @default.
• W2080932789 cites W1736071032 @default.
• W2080932789 cites W1851125727 @default.
• W2080932789 cites W1964512812 @default.
• W2080932789 cites W1964571316 @default.
• W2080932789 cites W1964950431 @default.
• W2080932789 cites W1964977567 @default.
• W2080932789 cites W1965346611 @default.
• W2080932789 cites W1966182087 @default.
• W2080932789 cites W1966839531 @default.
• W2080932789 cites W1967355242 @default.
• W2080932789 cites W1967800281 @default.
• W2080932789 cites W1968220176 @default.
• W2080932789 cites W1968668982 @default.
• W2080932789 cites W1968874615 @default.
• W2080932789 cites W1969772024 @default.
• W2080932789 cites W1970742251 @default.
• W2080932789 cites W1971053038 @default.
• W2080932789 cites W1971547791 @default.
• W2080932789 cites W1971607526 @default.
• W2080932789 cites W1971650902 @default.
• W2080932789 cites W1972444283 @default.
• W2080932789 cites W1973192598 @default.
• W2080932789 cites W1973872148 @default.
• W2080932789 cites W1974170731 @default.
• W2080932789 cites W1975485361 @default.
• W2080932789 cites W1975840004 @default.
• W2080932789 cites W1976249480 @default.
• W2080932789 cites W1976305162 @default.
• W2080932789 cites W1976556233 @default.
• W2080932789 cites W1977203383 @default.
• W2080932789 cites W1977547342 @default.
• W2080932789 cites W1977699006 @default.
• W2080932789 cites W1978562188 @default.
• W2080932789 cites W1978813311 @default.
• W2080932789 cites W1979315375 @default.
• W2080932789 cites W1980741612 @default.
• W2080932789 cites W1981181400 @default.
• W2080932789 cites W1981423842 @default.
• W2080932789 cites W1981756024 @default.
• W2080932789 cites W1982242118 @default.
• W2080932789 cites W1982252527 @default.
• W2080932789 cites W1983263104 @default.
• W2080932789 cites W1983600193 @default.
• W2080932789 cites W1983834933 @default.
• W2080932789 cites W1984164383 @default.
• W2080932789 cites W1984969980 @default.
• W2080932789 cites W1986087667 @default.
• W2080932789 cites W1986253399 @default.
• W2080932789 cites W1987264245 @default.
• W2080932789 cites W1988689887 @default.
• W2080932789 cites W1989165574 @default.
• W2080932789 cites W1989172094 @default.
• W2080932789 cites W1989552730 @default.
• W2080932789 cites W1989868511 @default.
• W2080932789 cites W1990105242 @default.
• W2080932789 cites W1991394590 @default.
• W2080932789 cites W1991477995 @default.
• W2080932789 cites W1992049866 @default.
• W2080932789 cites W1992486408 @default.
• W2080932789 cites W1993132699 @default.
• W2080932789 cites W1994193698 @default.
• W2080932789 cites W1994556922 @default.
• W2080932789 cites W1994994630 @default.
• W2080932789 cites W1995478179 @default.
• W2080932789 cites W1995680439 @default.
• W2080932789 cites W1995942931 @default.
• W2080932789 cites W1996335383 @default.
• W2080932789 cites W1996418962 @default.
• W2080932789 cites W1996834212 @default.
• W2080932789 cites W1996975556 @default.
• W2080932789 cites W1997822767 @default.
• W2080932789 cites W1999016451 @default.
• W2080932789 cites W1999538382 @default.
• W2080932789 cites W1999977514 @default.
• W2080932789 cites W2000397184 @default.
• W2080932789 cites W2001016740 @default.
• W2080932789 cites W2001035380 @default.
• W2080932789 cites W2002119844 @default.
• W2080932789 cites W2002131670 @default.
• W2080932789 cites W2002150564 @default.
• W2080932789 cites W2002273560 @default.
• W2080932789 cites W2002294810 @default.
• W2080932789 cites W2003761243 @default.
• W2080932789 cites W2004111202 @default.
• W2080932789 cites W2004142984 @default.
• W2080932789 cites W2006675789 @default.
• W2080932789 cites W2007346285 @default.

• next