Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080936432> ?p ?o ?g. }
- W2080936432 endingPage "317" @default.
- W2080936432 startingPage "304" @default.
- W2080936432 abstract "Summary: CD8 + T cells are crucial to the control of Trypanosoma cruzi infection and probably act via multiple mechanisms, the most important being the production of interferon‐γ (IFN‐γ). In the absence of CD8 + T cells, mice quickly succumb to the infection or develop a more severe chronic disease. Reduced production of IFN‐γ by CD8 + T cells is also associated with increased severity of chagasic disease in humans. CD8 + T cells in chronic T. cruzi infection are maintained as effector memory cells, undergo rapid expansion, and demonstrate effector functions following re‐exposure to antigen. However, the initial generation of T. cruzi ‐specific CD8 + T‐cell responses appears to be relatively slow to develop. In addition, the expression of the effector function of the CD8 + T cells is compromised in some tissues, particularly in muscle. The targets of effective CD8 + T‐cell responses in T. cruzi infection are multiple and varied, and they represent some of the best vaccine candidates described to date. Further analysis of CD8 + T cells will provide insight into the disease process in T. cruzi infection and should identify methods to assess and enhance immunity to T. cruzi infection and protection from the symptoms of Chagas' disease." @default.
- W2080936432 created "2016-06-24" @default.
- W2080936432 creator A5003065090 @default.
- W2080936432 creator A5064310918 @default.
- W2080936432 date "2004-09-10" @default.
- W2080936432 modified "2023-10-16" @default.
- W2080936432 title "Generation, specificity, and function of CD8+ T cells in Trypanosoma cruzi infection" @default.
- W2080936432 cites W1488666711 @default.
- W2080936432 cites W1494051466 @default.
- W2080936432 cites W1508365578 @default.
- W2080936432 cites W1512137623 @default.
- W2080936432 cites W1571283962 @default.
- W2080936432 cites W1576811007 @default.
- W2080936432 cites W1675195038 @default.
- W2080936432 cites W1870411326 @default.
- W2080936432 cites W1877588921 @default.
- W2080936432 cites W1896845502 @default.
- W2080936432 cites W1945834141 @default.
- W2080936432 cites W1968683690 @default.
- W2080936432 cites W1976358253 @default.
- W2080936432 cites W1979245971 @default.
- W2080936432 cites W1979905466 @default.
- W2080936432 cites W1981480494 @default.
- W2080936432 cites W1985528170 @default.
- W2080936432 cites W1992067375 @default.
- W2080936432 cites W1994340919 @default.
- W2080936432 cites W1995835059 @default.
- W2080936432 cites W1999805827 @default.
- W2080936432 cites W2003578744 @default.
- W2080936432 cites W2004153416 @default.
- W2080936432 cites W2010749211 @default.
- W2080936432 cites W2013824064 @default.
- W2080936432 cites W2016325370 @default.
- W2080936432 cites W2020113626 @default.
- W2080936432 cites W2023552479 @default.
- W2080936432 cites W2029128444 @default.
- W2080936432 cites W2031278032 @default.
- W2080936432 cites W2043400760 @default.
- W2080936432 cites W2044633977 @default.
- W2080936432 cites W2050989136 @default.
- W2080936432 cites W2051539436 @default.
- W2080936432 cites W2052528673 @default.
- W2080936432 cites W2061212799 @default.
- W2080936432 cites W2062472841 @default.
- W2080936432 cites W2063695575 @default.
- W2080936432 cites W2070309039 @default.
- W2080936432 cites W2072652751 @default.
- W2080936432 cites W2073469002 @default.
- W2080936432 cites W2073501462 @default.
- W2080936432 cites W2076896267 @default.
- W2080936432 cites W2076986024 @default.
- W2080936432 cites W2080778028 @default.
- W2080936432 cites W2086987955 @default.
- W2080936432 cites W2094724411 @default.
- W2080936432 cites W2094795612 @default.
- W2080936432 cites W2096252590 @default.
- W2080936432 cites W2097910039 @default.
- W2080936432 cites W2103252821 @default.
- W2080936432 cites W2104963174 @default.
- W2080936432 cites W2106266051 @default.
- W2080936432 cites W2108909957 @default.
- W2080936432 cites W2112434543 @default.
- W2080936432 cites W2117594406 @default.
- W2080936432 cites W2118600639 @default.
- W2080936432 cites W2123061584 @default.
- W2080936432 cites W2123871986 @default.
- W2080936432 cites W2124542225 @default.
- W2080936432 cites W2135238347 @default.
- W2080936432 cites W2137586571 @default.
- W2080936432 cites W2139112575 @default.
- W2080936432 cites W2141391374 @default.
- W2080936432 cites W2141634438 @default.
- W2080936432 cites W2142847607 @default.
- W2080936432 cites W2145318249 @default.
- W2080936432 cites W2146193951 @default.
- W2080936432 cites W2156305705 @default.
- W2080936432 cites W2156608616 @default.
- W2080936432 cites W2157118114 @default.
- W2080936432 cites W2158579619 @default.
- W2080936432 cites W2158849024 @default.
- W2080936432 cites W2159271852 @default.
- W2080936432 cites W2164254316 @default.
- W2080936432 cites W2252687061 @default.
- W2080936432 cites W2413727084 @default.
- W2080936432 cites W2429845057 @default.
- W2080936432 cites W2608071918 @default.
- W2080936432 cites W4243504150 @default.
- W2080936432 doi "https://doi.org/10.1111/j.0105-2896.2004.00183.x" @default.
- W2080936432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15361249" @default.
- W2080936432 hasPublicationYear "2004" @default.
- W2080936432 type Work @default.
- W2080936432 sameAs 2080936432 @default.
- W2080936432 citedByCount "145" @default.
- W2080936432 countsByYear W20809364322012 @default.
- W2080936432 countsByYear W20809364322013 @default.
- W2080936432 countsByYear W20809364322014 @default.
- W2080936432 countsByYear W20809364322015 @default.
- W2080936432 countsByYear W20809364322016 @default.