Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080941711> ?p ?o ?g. }
- W2080941711 endingPage "549" @default.
- W2080941711 startingPage "539" @default.
- W2080941711 abstract "We evaluated the efficacy of aerosolized acetylcholinesterase (AChE) reactivator oxime MMB-4 in combination with the anticholinergic atropine sulfate for protection against respiratory toxicity and lung injury following microinstillation inhalation exposure to nerve agent soman (GD) in guinea pigs. Anesthetized animals were exposed to GD (841 mg/m3, 1.2 LCt50) and treated with endotracheally aerosolized MMB-4 (50 µmol/kg) plus atropine sulfate (0.25 mg/kg) at 30 sec post-exposure. Treatment with MMB-4 plus atropine increased survival to 100% compared to 38% in animals exposed to GD. Decreases in the pulse rate and blood O2 saturation following exposure to GD returned to normal levels in the treatment group. The body-weight loss and lung edema was significantly reduced in the treatment group. Similarly, bronchoalveolar cell death was significantly reduced in the treatment group while GD-induced increase in total cell count was decreased consistently but was not significant. GD-induced increase in bronchoalveolar protein was diminished after treatment with MMB-4 plus atropine. Bronchoalveolar lavage AChE and BChE activity were significantly increased in animals treated with MMB-4 plus atropine at 24 h. Lung and diaphragm tissue also showed a significant increase in AChE activity in the treatment group. Treatment with MMB-4 plus atropine sulfate normalized various respiratory dynamics parameters including respiratory frequency, tidal volume, peak inspiratory and expiratory flow, time of inspiration and expiration, enhanced pause and pause post-exposure to GD. Collectively, these results suggest that aerosolization of MMB-4 plus atropine increased survival, decreased respiratory toxicity and lung injury following GD inhalation exposure." @default.
- W2080941711 created "2016-06-24" @default.
- W2080941711 creator A5015806419 @default.
- W2080941711 creator A5017819842 @default.
- W2080941711 creator A5029176560 @default.
- W2080941711 creator A5036469707 @default.
- W2080941711 creator A5054057007 @default.
- W2080941711 creator A5066112299 @default.
- W2080941711 creator A5071849446 @default.
- W2080941711 creator A5072406539 @default.
- W2080941711 creator A5089131205 @default.
- W2080941711 date "2012-08-01" @default.
- W2080941711 modified "2023-09-27" @default.
- W2080941711 title "Aerosolized delivery of oxime MMB-4 in combination with atropine sulfate protects against soman exposure in guinea pigs" @default.
- W2080941711 cites W1778515962 @default.
- W2080941711 cites W1965030025 @default.
- W2080941711 cites W1966755219 @default.
- W2080941711 cites W1971857258 @default.
- W2080941711 cites W1974722521 @default.
- W2080941711 cites W1980239503 @default.
- W2080941711 cites W1992748682 @default.
- W2080941711 cites W1994907581 @default.
- W2080941711 cites W2000532155 @default.
- W2080941711 cites W2003343310 @default.
- W2080941711 cites W2004223808 @default.
- W2080941711 cites W2007130712 @default.
- W2080941711 cites W2007324776 @default.
- W2080941711 cites W2007932933 @default.
- W2080941711 cites W2010195030 @default.
- W2080941711 cites W2014652437 @default.
- W2080941711 cites W2018103446 @default.
- W2080941711 cites W2029344593 @default.
- W2080941711 cites W2038534953 @default.
- W2080941711 cites W2038600241 @default.
- W2080941711 cites W2040712358 @default.
- W2080941711 cites W2041266633 @default.
- W2080941711 cites W2043870768 @default.
- W2080941711 cites W2046294255 @default.
- W2080941711 cites W2048531848 @default.
- W2080941711 cites W2056774826 @default.
- W2080941711 cites W2059964942 @default.
- W2080941711 cites W2068680388 @default.
- W2080941711 cites W2073492302 @default.
- W2080941711 cites W2079900948 @default.
- W2080941711 cites W2079960443 @default.
- W2080941711 cites W2083065709 @default.
- W2080941711 cites W2086770126 @default.
- W2080941711 cites W2103509572 @default.
- W2080941711 cites W2111359173 @default.
- W2080941711 cites W2117288276 @default.
- W2080941711 cites W2127594954 @default.
- W2080941711 cites W2138307684 @default.
- W2080941711 cites W2139232904 @default.
- W2080941711 cites W2143984301 @default.
- W2080941711 cites W2146297864 @default.
- W2080941711 cites W2154463500 @default.
- W2080941711 cites W4246262570 @default.
- W2080941711 doi "https://doi.org/10.3109/08958378.2012.691912" @default.
- W2080941711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22860999" @default.
- W2080941711 hasPublicationYear "2012" @default.
- W2080941711 type Work @default.
- W2080941711 sameAs 2080941711 @default.
- W2080941711 citedByCount "6" @default.
- W2080941711 countsByYear W20809417112013 @default.
- W2080941711 countsByYear W20809417112014 @default.
- W2080941711 countsByYear W20809417112018 @default.
- W2080941711 countsByYear W20809417112019 @default.
- W2080941711 countsByYear W20809417112020 @default.
- W2080941711 countsByYear W20809417112021 @default.
- W2080941711 crossrefType "journal-article" @default.
- W2080941711 hasAuthorship W2080941711A5015806419 @default.
- W2080941711 hasAuthorship W2080941711A5017819842 @default.
- W2080941711 hasAuthorship W2080941711A5029176560 @default.
- W2080941711 hasAuthorship W2080941711A5036469707 @default.
- W2080941711 hasAuthorship W2080941711A5054057007 @default.
- W2080941711 hasAuthorship W2080941711A5066112299 @default.
- W2080941711 hasAuthorship W2080941711A5071849446 @default.
- W2080941711 hasAuthorship W2080941711A5072406539 @default.
- W2080941711 hasAuthorship W2080941711A5089131205 @default.
- W2080941711 hasConcept C126322002 @default.
- W2080941711 hasConcept C181199279 @default.
- W2080941711 hasConcept C185592680 @default.
- W2080941711 hasConcept C2775859210 @default.
- W2080941711 hasConcept C2776327929 @default.
- W2080941711 hasConcept C2777714996 @default.
- W2080941711 hasConcept C2777961210 @default.
- W2080941711 hasConcept C2778816929 @default.
- W2080941711 hasConcept C2780266723 @default.
- W2080941711 hasConcept C29730261 @default.
- W2080941711 hasConcept C42219234 @default.
- W2080941711 hasConcept C55493867 @default.
- W2080941711 hasConcept C71924100 @default.
- W2080941711 hasConcept C98274493 @default.
- W2080941711 hasConceptScore W2080941711C126322002 @default.
- W2080941711 hasConceptScore W2080941711C181199279 @default.
- W2080941711 hasConceptScore W2080941711C185592680 @default.
- W2080941711 hasConceptScore W2080941711C2775859210 @default.
- W2080941711 hasConceptScore W2080941711C2776327929 @default.