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- W2080950867 abstract "Urocortins are human homologues of urotensin I, a fish corticotropin-releasing-factor- (CRF-) like peptide secreted from the urophysis. There are three urocortins: urocortin 1, urocortin 2, and urocortin 3 in mammals. We have shown that urocortin 1 and urocortin 3 are endogenously synthesized in the myocardial cells of human heart and may act on CRF type 2 receptor (CRFR2) expressed in the heart. Expression levels of urocortin 1 in the heart and plasma urocortin 1 levels are elevated in patients with heart failure. Recent studies have shown that urocortins have various biological actions in the cardiovascular system, such as a vasodilator action, a positive inotropic action, a cardioprotective action against ischemia/reperfusion injury, and suppressive actions against the renin angiotensin system and the sympathetic nervous system. Urocortins and CRFR2 may therefore be a potential therapeutic target for cardiovascular diseases, such as congestive heart failure, hypertension, and myocardial infarction." @default.
- W2080950867 created "2016-06-24" @default.
- W2080950867 creator A5091608515 @default.
- W2080950867 date "2012-01-01" @default.
- W2080950867 modified "2023-09-25" @default.
- W2080950867 title "Distribution of Urocortins and Corticotropin-Releasing Factor Receptors in the Cardiovascular System" @default.
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- W2080950867 doi "https://doi.org/10.1155/2012/395284" @default.
- W2080950867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3362921" @default.
- W2080950867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22675352" @default.
- W2080950867 hasPublicationYear "2012" @default.
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