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- W2080962275 abstract "Mimosa caesalpiniifolia (Fabaceae: Mimosoideae), popularly known as “sabiá” or “sansão-do-campo” is a Brazilian Northeast native perennial tree used for several purposes and in traditional medicine [1,2]. The aim of this study was to evaluate the antigenotoxic and antioxidant activity induced by ethanolic extract (EEM) and ethyl acetate fraction (EAM) of M. caesalpiniifolia leaves in multiple rodent organs subjected to intoxication with cadmium chloride. A total of 35 Wistar rats were distributed into seven groups (n = 5): Control group (non-treated); Cadmium group (Cd); cadmium group and EEM 62.5 mg/kg/day; cadmium group and EEM 125 mg/kg/day; cadmium and EEM 250 mg/kg/day; cadmium and EAM 62.5 mg/kg/day. For evaluating the toxicogenetic potential of two groups were treated with EEM 250 mg/kg/day and EAM 62.5 mg/kd/day, respectively. EEM and EAM presented 46.8 and 71.50 g gallic acid equivalents/kg with an antioxidant activity of 35.3 and 65.3 g vitamin C equivalents/kg. EEM at concentrations of 62.5 mg (blood: 1.7 ± 0.3 and liver: 2.0 ± 0.4) and 125 mg (blood: 1.3 ± 0.5 and liver: 1.1 ± 0.2) decreased DNA damage by single cell gel (comet) assay [3] in animals intoxicated with cadmium were significantly (p < 0.05) when compared to cadmium group (blood: 2.8 ± 0.3 and liver: 3.6 ± 0.9). In a similar manner, treatment with EAM at 62.5 mg (blood: 1.5 ± 0.2 and liver: 1.0 ± 0.5) reduced genetic damage in peripheral blood cells. In a similar manner, the treatment with EAM reduced DNA damage in liver cells. Oxidative DNA damage was reduced at 125 mg EEM (3.7 ± 0.5) as well as 62.5 mg EAM (3.2 ± 0.8) were significantly (p < 0.05) when compared to cadmium group (6.3 ± 0.8). The experimental results suggests that the biologically active substances of catechin and procyanidin B2 [(epi)catechin-(epi)catechin)] present in the EEM and EAM of plant M. caesalpiniifolia, may be responsible for the significant reduction of genotoxicity induced by cadmium exposure in liver and peripheral blood cells of rats." @default.
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- W2080962275 date "2014-10-30" @default.
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- W2080962275 title "Ethanolic extract of Mimosa caesalpiniifolia leaves: Modulates chemically induced genotoxicity by cadmium exposure in liver and blood cells of rats" @default.
- W2080962275 doi "https://doi.org/10.1055/s-0034-1394688" @default.
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