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• W2080962348 abstract "The aim of this work was to evaluate the hepatic effects of toxic and subtoxic doses of paraquat, using a primary culture of adult rat hepatocytes as an experimental model. Concentrations in culture ranged from 10(-3) to 10(-9)m-paraquat. When added to cultures at the time of plating 10(-3)m-paraquat impaired hepatocyte spreading on the substratum and caused cell death which was preceded by a leakage of cytosolic enzymes (lactate dehydrogenase, glutamic-oxaloacetic transaminase). When added to 24-hr cultures, effects on the metabolism of the hepatocytes were observed at paraquat concentrations of 10(-3) and 10(-4)m but not at lower concentrations. In comparison with controls, when paraquat was present at 10(-3)m, gluconeogenesis from fructose and lactate was inhibited by 40 and 58%, respectively, ureogenesis was inhibited by 16% and the albumin synthesis rate was reduced by 62%. The intracellular content of the reduced form of glutathione decreased by 33% and was parallelled by an increase in the oxidized form of glutathione. However, neither cytotoxic nor metabolic effects were observed in cells exposed to 10(-5)m, the concentration found in blood after acute intoxication with paraquat." @default.
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• W2080962348 date "1988-01-01" @default.
• W2080962348 modified "2023-09-27" @default.
• W2080962348 title "Hepatic toxicity of paraquat in primary cultures of rat hepatocytes" @default.
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• W2080962348 doi "https://doi.org/10.1016/0887-2333(88)90046-x" @default.
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