Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080962355> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2080962355 endingPage "1131" @default.
- W2080962355 startingPage "1125" @default.
- W2080962355 abstract "Benz[j]aceanthrylene (B[j]A) and benz[l)aceanthrylene (B[l]A), two isomeric cyclopenta polycyclic aromatic hydrocarbons (CP-PAH) structurally related to 3-methylcholanthrene, were studied with respect to their genotoxic effects in isolated liver and lung cells. Both compounds were found to cause DNA adducts measured by the 32P-postlabelling technique. The level of DNA-adducts in rat hepatocytes exposed to 30 μg/ml B[l]A and B[j]A for 4 h were 46.5 ± 22.0 and 8.3 ± 5.1 fmol/μg DNA respectively. Using butanol extractions, the major and one of the minor B[l] A adducts co-chromatographed with B[j]A-l, 2-oxide adducts of 2'-deoxyadenosine and 2'-deoxyguanosine. Thus, oxidation at the cyclopenta-ring of B[j]A appears to be an important activation pathway. In hepatocytes, 3-30 μg/ml of B[j]A and B[j]A induced DNA damage and repair measured both as increased alkaline elution of DNA and as increased incorporation of [3H]TdR in the DNA. B[l]A was somewhat more potent than B[j]A in inducing DNA repair. Reactive CP-PAH intermediates formed in the hepatocytes caused mutations in Salmonella typhimurium TA98 upon co-incubation. DNA adducts were also observed in isolated rabbit lung cells exposed to 30 μg/ml B[l]A or B[j]A for 2 h. A total of 14.5 ± 6.9, 2.9 ± 2.1 and 0.2 ± 0.6 fmol B[l] A adducts/μg DNA were observed in Clara cells, type II pneumocytes and alveolar macrophages respectively. The main B[l]A adduct observed in the liver cells was not found in the lung cells. On the other hand, the levels of B[j]A adducts in the lung cells were in the range 4-14% of that found in liver cells, and no major differences between the various lung cells were observed. Neither B[l]A nor B[j]A induced DNA damage measured by alkaline elution in the lung cells, indicating that these adducts are not alkali labile." @default.
- W2080962355 created "2016-06-24" @default.
- W2080962355 creator A5004246712 @default.
- W2080962355 creator A5006674415 @default.
- W2080962355 creator A5011676965 @default.
- W2080962355 creator A5014221194 @default.
- W2080962355 creator A5014466291 @default.
- W2080962355 creator A5033189663 @default.
- W2080962355 creator A5055052895 @default.
- W2080962355 creator A5066023889 @default.
- W2080962355 creator A5079997874 @default.
- W2080962355 creator A5080154408 @default.
- W2080962355 date "1993-01-01" @default.
- W2080962355 modified "2023-10-16" @default.
- W2080962355 title "Genotoxic effects of cyclopenta-fused polycyclic aromatic hydrocarbons in isolated rat hepatocytes and rabbit lung cells" @default.
- W2080962355 doi "https://doi.org/10.1093/carcin/14.6.1125" @default.
- W2080962355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8508497" @default.
- W2080962355 hasPublicationYear "1993" @default.
- W2080962355 type Work @default.
- W2080962355 sameAs 2080962355 @default.
- W2080962355 citedByCount "7" @default.
- W2080962355 countsByYear W20809623552015 @default.
- W2080962355 countsByYear W20809623552021 @default.
- W2080962355 crossrefType "journal-article" @default.
- W2080962355 hasAuthorship W2080962355A5004246712 @default.
- W2080962355 hasAuthorship W2080962355A5006674415 @default.
- W2080962355 hasAuthorship W2080962355A5011676965 @default.
- W2080962355 hasAuthorship W2080962355A5014221194 @default.
- W2080962355 hasAuthorship W2080962355A5014466291 @default.
- W2080962355 hasAuthorship W2080962355A5033189663 @default.
- W2080962355 hasAuthorship W2080962355A5055052895 @default.
- W2080962355 hasAuthorship W2080962355A5066023889 @default.
- W2080962355 hasAuthorship W2080962355A5079997874 @default.
- W2080962355 hasAuthorship W2080962355A5080154408 @default.
- W2080962355 hasConcept C108204754 @default.
- W2080962355 hasConcept C114246631 @default.
- W2080962355 hasConcept C143425029 @default.
- W2080962355 hasConcept C153911025 @default.
- W2080962355 hasConcept C178790620 @default.
- W2080962355 hasConcept C185592680 @default.
- W2080962355 hasConcept C2780441211 @default.
- W2080962355 hasConcept C2780636463 @default.
- W2080962355 hasConcept C2781247443 @default.
- W2080962355 hasConcept C552990157 @default.
- W2080962355 hasConcept C55493867 @default.
- W2080962355 hasConcept C71240020 @default.
- W2080962355 hasConcept C86803240 @default.
- W2080962355 hasConceptScore W2080962355C108204754 @default.
- W2080962355 hasConceptScore W2080962355C114246631 @default.
- W2080962355 hasConceptScore W2080962355C143425029 @default.
- W2080962355 hasConceptScore W2080962355C153911025 @default.
- W2080962355 hasConceptScore W2080962355C178790620 @default.
- W2080962355 hasConceptScore W2080962355C185592680 @default.
- W2080962355 hasConceptScore W2080962355C2780441211 @default.
- W2080962355 hasConceptScore W2080962355C2780636463 @default.
- W2080962355 hasConceptScore W2080962355C2781247443 @default.
- W2080962355 hasConceptScore W2080962355C552990157 @default.
- W2080962355 hasConceptScore W2080962355C55493867 @default.
- W2080962355 hasConceptScore W2080962355C71240020 @default.
- W2080962355 hasConceptScore W2080962355C86803240 @default.
- W2080962355 hasIssue "6" @default.
- W2080962355 hasLocation W20809623551 @default.
- W2080962355 hasLocation W20809623552 @default.
- W2080962355 hasOpenAccess W2080962355 @default.
- W2080962355 hasPrimaryLocation W20809623551 @default.
- W2080962355 hasRelatedWork W1977915969 @default.
- W2080962355 hasRelatedWork W2012588975 @default.
- W2080962355 hasRelatedWork W2022653668 @default.
- W2080962355 hasRelatedWork W2049862580 @default.
- W2080962355 hasRelatedWork W2055683447 @default.
- W2080962355 hasRelatedWork W2079902812 @default.
- W2080962355 hasRelatedWork W2129485292 @default.
- W2080962355 hasRelatedWork W2148913517 @default.
- W2080962355 hasRelatedWork W2149602703 @default.
- W2080962355 hasRelatedWork W2797934237 @default.
- W2080962355 hasVolume "14" @default.
- W2080962355 isParatext "false" @default.
- W2080962355 isRetracted "false" @default.
- W2080962355 magId "2080962355" @default.
- W2080962355 workType "article" @default.