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- W2080965551 abstract "Fluid secretion in the isolated rabbit ciliary body was measured with zero pressure gradient across the tissue and fluid flows were measured under an hydrostatic pressure gradient. The active component of marihuana, Δ1-tetrahydrocannabinol (Δ1-THC), when applied in vitro to the tissue reduced secretion and increased passive permeability. The effective concentrations of Δ1-THC were equivalent to those found in human plasma following absorption of the drug. Fluid secretion was reduced by about 70% at 5×10−5 mg/ml, and the short-circuit current was reduced by about 45%. The hydraulic conductivity increased by 70% over control values. Intravenously administered Δ1-THC (giving a plasma concentration of 50×10−6 mg/ml for a plasma volume of 200 ml) produced the following results in the living rabbit: (a) a transient increase in heart rate of 15% after 10–15 min; (b) a reduction in intraocular pressure, with a maximum of 25–30% after 50–60 min; (c) an increase of 60–70% in total facility, and (d) an increase (100%) in aqueous protein. Marihuana reduces intraocular pressure and may act by causing a reduction in ciliary capillary pressure which would cause a decreased formation rate. Vasoconstriction could also cause an increase in aqueous outflow, since aqueous and blood compete for the same episcleral outflow vessels." @default.
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- W2080965551 date "1973-04-01" @default.
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- W2080965551 title "Effect of Δ1-tetrahydrocannabinol on aqueous dynamics and ciliary body permeability in the rabbit" @default.
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- W2080965551 doi "https://doi.org/10.1016/0014-4835(73)90142-5" @default.
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