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• W2080966483 abstract "We have examined cross-resistance between trypanocidal drugs using a well-characterised drug-sensitive line, 247, and its cymelarsan-resistant derivative, 247melCyR. The cymelarsan-resistant line was cross-resistant to trimelarsen and melarsen oxide, and partially cross-resistant to two diamidines, pentamidine and berenil (diminazene aceturate). It was cross-resistant to lipid-soluble melarsoprolin vivobut to only a trivial degree in twoin vitroassays. The potential role of adenosine transport in arsenical-induced killing of parasites was investigated. Adenosine, adenine, and the diamidines, but not inosine, were able to inhibit killing of drug-sensitive STIB 247 trypanosomes by cymelarsan and melarsen oxide in a concentration-dependent manner. These results are consistent with the view that these arsenical compounds enter trypanosomes via an adenosine-specific transporter. Melarsoprol-induced killing of trypanosomes was unaffected, however, by either purine and to only a slight degree by the diamidines. These data suggest that melarsoprol can enter trypanosomes by a route other than through an adenosine transporter and that there may be two mechanisms contributing to arsenical resistance in this drug-resistant line of trypanosomes." @default.
• W2080966483 created "2016-06-24" @default.
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• W2080966483 date "1997-07-01" @default.
• W2080966483 modified "2023-10-13" @default.
• W2080966483 title "Trypanosoma brucei:Lack of Cross-resistance to Melarsoprolin Vitroby Cymelarsan-Resistant Parasites" @default.
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• W2080966483 doi "https://doi.org/10.1006/expr.1997.4167" @default.
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