FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080970129> ?p ?o ?g. }

• W2080970129 abstract "Store-operated calcium entry is a nearly ubiquitous signaling pathway in eukaryotic cells. The plasma membrane store-operated channels are comprised of subunits of the recently discovered Orai proteins, the major one being Orai1.We have discovered that native Orai1 as well as expressed Orai1 exists in two forms in similar quantities: a longer form (Orai1α) of approximately 33 kDa, and a shorter form (Orai1β) of approximately 23 kDa. The second Orai1β form arises from alternative translation initiation from a methionine at position 64, and possibly also 71, in the longer, Orai1α form. In the sequence upstream of the initiation site of Orai1β, there is a poly-arginine sequence previously suggested to be involved in interaction of Orai1 with plasma membrane phosphatidylinositol 4,5-bisphosphate. The loss of this phospholipid binding domain would be expected to influence the mobility of Orai1 protein in the plasma membrane. Indeed, experiments utilizing fluorescence recovery after photobleaching (FRAP) revealed that the recovery half-time for Orai1β was significantly faster than for Orai1α. Since Orai1 must diffuse to sites of interaction with the Ca2+ sensor, STIM1, these two mobilities might provide for efficient recruitment of Orai1 subunits to sites of store-operated Ca2+ entry during agonist-induced Ca2+ signaling." @default.
• W2080970129 created "2016-06-24" @default.
• W2080970129 creator A5004837365 @default.
• W2080970129 creator A5041549546 @default.
• W2080970129 creator A5046782423 @default.
• W2080970129 creator A5060890309 @default.
• W2080970129 date "2012-01-01" @default.
• W2080970129 modified "2023-10-14" @default.
• W2080970129 title "Alternative translation initiation gives rise to two isoforms of orai1 with distinct plasma membrane mobilities" @default.
• W2080970129 cites W1599269500 @default.
• W2080970129 cites W1668594850 @default.
• W2080970129 cites W1975297292 @default.
• W2080970129 cites W1978300668 @default.
• W2080970129 cites W1978593035 @default.
• W2080970129 cites W1993781709 @default.
• W2080970129 cites W2001917660 @default.
• W2080970129 cites W2006982169 @default.
• W2080970129 cites W2016348702 @default.
• W2080970129 cites W2020708758 @default.
• W2080970129 cites W2025221100 @default.
• W2080970129 cites W2029301182 @default.
• W2080970129 cites W2042144124 @default.
• W2080970129 cites W2044995847 @default.
• W2080970129 cites W2058622754 @default.
• W2080970129 cites W2059989081 @default.
• W2080970129 cites W2060202251 @default.
• W2080970129 cites W2063048358 @default.
• W2080970129 cites W2070832223 @default.
• W2080970129 cites W2086104179 @default.
• W2080970129 cites W2086264391 @default.
• W2080970129 cites W2090706449 @default.
• W2080970129 cites W2094085710 @default.
• W2080970129 cites W2097439505 @default.
• W2080970129 cites W2101586949 @default.
• W2080970129 cites W2108183974 @default.
• W2080970129 cites W2118478876 @default.
• W2080970129 cites W2118988881 @default.
• W2080970129 cites W2119682654 @default.
• W2080970129 cites W2128783251 @default.
• W2080970129 cites W2144543766 @default.
• W2080970129 cites W2146341872 @default.
• W2080970129 cites W2158652398 @default.
• W2080970129 cites W2163789582 @default.
• W2080970129 cites W4255268623 @default.
• W2080970129 doi "https://doi.org/10.1242/jcs.104919" @default.
• W2080970129 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3516440" @default.
• W2080970129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22641696" @default.
• W2080970129 hasPublicationYear "2012" @default.
• W2080970129 type Work @default.
• W2080970129 sameAs 2080970129 @default.
• W2080970129 citedByCount "79" @default.
• W2080970129 countsByYear W20809701292013 @default.
• W2080970129 countsByYear W20809701292014 @default.
• W2080970129 countsByYear W20809701292015 @default.
• W2080970129 countsByYear W20809701292016 @default.
• W2080970129 countsByYear W20809701292017 @default.
• W2080970129 countsByYear W20809701292018 @default.
• W2080970129 countsByYear W20809701292019 @default.
• W2080970129 countsByYear W20809701292020 @default.
• W2080970129 countsByYear W20809701292021 @default.
• W2080970129 countsByYear W20809701292022 @default.
• W2080970129 countsByYear W20809701292023 @default.
• W2080970129 crossrefType "journal-article" @default.
• W2080970129 hasAuthorship W2080970129A5004837365 @default.
• W2080970129 hasAuthorship W2080970129A5041549546 @default.
• W2080970129 hasAuthorship W2080970129A5046782423 @default.
• W2080970129 hasAuthorship W2080970129A5060890309 @default.
• W2080970129 hasBestOaLocation W20809701291 @default.
• W2080970129 hasConcept C104292427 @default.
• W2080970129 hasConcept C104317684 @default.
• W2080970129 hasConcept C12554922 @default.
• W2080970129 hasConcept C158617107 @default.
• W2080970129 hasConcept C162740809 @default.
• W2080970129 hasConcept C26659971 @default.
• W2080970129 hasConcept C2776610495 @default.
• W2080970129 hasConcept C2780610907 @default.
• W2080970129 hasConcept C41625074 @default.
• W2080970129 hasConcept C55493867 @default.
• W2080970129 hasConcept C62478195 @default.
• W2080970129 hasConcept C86803240 @default.
• W2080970129 hasConcept C95444343 @default.
• W2080970129 hasConceptScore W2080970129C104292427 @default.
• W2080970129 hasConceptScore W2080970129C104317684 @default.
• W2080970129 hasConceptScore W2080970129C12554922 @default.
• W2080970129 hasConceptScore W2080970129C158617107 @default.
• W2080970129 hasConceptScore W2080970129C162740809 @default.
• W2080970129 hasConceptScore W2080970129C26659971 @default.
• W2080970129 hasConceptScore W2080970129C2776610495 @default.
• W2080970129 hasConceptScore W2080970129C2780610907 @default.
• W2080970129 hasConceptScore W2080970129C41625074 @default.
• W2080970129 hasConceptScore W2080970129C55493867 @default.
• W2080970129 hasConceptScore W2080970129C62478195 @default.
• W2080970129 hasConceptScore W2080970129C86803240 @default.
• W2080970129 hasConceptScore W2080970129C95444343 @default.
• W2080970129 hasLocation W20809701291 @default.
• W2080970129 hasLocation W20809701292 @default.
• W2080970129 hasLocation W20809701293 @default.
• W2080970129 hasLocation W20809701294 @default.
• W2080970129 hasOpenAccess W2080970129 @default.
• W2080970129 hasPrimaryLocation W20809701291 @default.

• next