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- W2080970775 abstract "To assess the changes in endometrial thickness in postmenopausal women receiving low-dose HRT. One year, prospective, open label study. Inclusion criteria: women aged over 47 years, at least one year after last menstrual period, with menopausal symptoms (hot flushes, night sweat, mood swings, sleeping problems, etc.), whose FSH and E2 were within the menopausal range. Exclusion criteria: endometrial biopsy showing malignant or premalignant changes, Pap smear class III or more, mammographic signs of malignancy, severe liver impairment, uncontrolled arterial hypertension and diabetes. The screening visit included clinical and gynecological exam, transvaginal ultrasound (TVUS) to assess endometrial thickness and status of the uterus and ovaries, followed by endometrial biopsy. Mammography and Pap smear were also performed. The visits consisted of TVUS for endometrial thickness every 3 months, beside vital signs assessment, bleeding patterns and QOL evaluation. The final visit included the same assessments as in the screening visit. Patients received 0.5 mg 17β estradiol combined with 2.5 mg dydrogesterone, once a day for 12 months ± 2 weeks. From 120 patients, 117 matched the inclusion criteria and 105 ended the study. Endometrial thickness assessed by TVUS showed no significant modifications in 97 patients, while eight patients had a 50% increase in endometrial thickness compared with baseline value. There was no transition of endometrial histology towards premalignancy or malignancy in all 105 patients. There was a substantial improvement in the menopausal symptoms in 87 patients, 16 showed a slight improvement and two had no modification. Low-dose continuous HRT combined regimen with 17β estradiol/dydrogesterone in postmenopausal women proved to be safe as regards to endometrial thickness as well as histological structure, while preserving beneficial effects on menopausal symptoms." @default.
- W2080970775 created "2016-06-24" @default.
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- W2080970775 date "2007-09-21" @default.
- W2080970775 modified "2023-09-27" @default.
- W2080970775 title "OP17.01: Endometrial thickness assessed by ultrasound in the postmenopausal patient receiving HRT" @default.
- W2080970775 doi "https://doi.org/10.1002/uog.4579" @default.
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