FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080973344> ?p ?o ?g. }

• W2080973344 endingPage "300" @default.
• W2080973344 startingPage "296" @default.
• W2080973344 abstract "We report the occurrence of an isomerase with a putative (betaalpha)(8)-barrel structure involved in both histidine and trypto-phan biosynthesis in Streptomyces coelicolor A3(2) and Mycobacterium tuberculosis HR37Rv. Deletion of a hisA homologue (SCO2050) putatively encoding N'-[(5'-phosphoribosyl)-formimino]-5 amino-imidazole-4-carboxamide ribonucleotide isomerase from the chromosome of S. coelicolor A3(2) generated a double auxotrophic mutant for histidine and tryptophan. The bifunctional gene SCO2050 and its orthologue Rv1603 from M. tuberculosis complemented both hisA and trpF mutants of Escherichia coli. Expression of the E. coli trpF gene in the S. coelicolor mutant only complemented the tryptophan auxo-trophy, and the hisA gene only complemented the histidine auxotrophy. The discovery of this enzyme, which has a broad-substrate specificity, has implications for the evolution of metabolic pathways and may prove to be important for understanding the evolution of the (betaalpha)(8)-barrels." @default.
• W2080973344 created "2016-06-24" @default.
• W2080973344 creator A5083120097 @default.
• W2080973344 creator A5083255554 @default.
• W2080973344 date "2003-02-21" @default.
• W2080973344 modified "2023-10-14" @default.
• W2080973344 title "Occurrence of a putative ancient‐like isomerase involved in histidine and tryptophan biosynthesis" @default.
• W2080973344 cites W1513678377 @default.
• W2080973344 cites W1951749689 @default.
• W2080973344 cites W1966833977 @default.
• W2080973344 cites W1971496061 @default.
• W2080973344 cites W1978940662 @default.
• W2080973344 cites W1987345363 @default.
• W2080973344 cites W1987960749 @default.
• W2080973344 cites W1990163323 @default.
• W2080973344 cites W1998238795 @default.
• W2080973344 cites W2000118138 @default.
• W2080973344 cites W2003788979 @default.
• W2080973344 cites W2012465378 @default.
• W2080973344 cites W2012960603 @default.
• W2080973344 cites W2017668812 @default.
• W2080973344 cites W2023950913 @default.
• W2080973344 cites W2030461124 @default.
• W2080973344 cites W2032741251 @default.
• W2080973344 cites W2046882774 @default.
• W2080973344 cites W2059251856 @default.
• W2080973344 cites W2091642257 @default.
• W2080973344 cites W2103731920 @default.
• W2080973344 cites W2110723813 @default.
• W2080973344 cites W2112492958 @default.
• W2080973344 cites W2120617559 @default.
• W2080973344 cites W2121704271 @default.
• W2080973344 cites W2140244239 @default.
• W2080973344 cites W2148849489 @default.
• W2080973344 cites W2158023121 @default.
• W2080973344 cites W2158714788 @default.
• W2080973344 cites W2164217177 @default.
• W2080973344 cites W2164218520 @default.
• W2080973344 cites W2164425579 @default.
• W2080973344 cites W2195878577 @default.
• W2080973344 doi "https://doi.org/10.1038/sj.embor.embor771" @default.
• W2080973344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1315899" @default.
• W2080973344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12634849" @default.
• W2080973344 hasPublicationYear "2003" @default.
• W2080973344 type Work @default.
• W2080973344 sameAs 2080973344 @default.
• W2080973344 citedByCount "81" @default.
• W2080973344 countsByYear W20809733442012 @default.
• W2080973344 countsByYear W20809733442013 @default.
• W2080973344 countsByYear W20809733442014 @default.
• W2080973344 countsByYear W20809733442015 @default.
• W2080973344 countsByYear W20809733442016 @default.
• W2080973344 countsByYear W20809733442017 @default.
• W2080973344 countsByYear W20809733442018 @default.
• W2080973344 countsByYear W20809733442019 @default.
• W2080973344 countsByYear W20809733442020 @default.
• W2080973344 countsByYear W20809733442022 @default.
• W2080973344 countsByYear W20809733442023 @default.
• W2080973344 crossrefType "journal-article" @default.
• W2080973344 hasAuthorship W2080973344A5083120097 @default.
• W2080973344 hasAuthorship W2080973344A5083255554 @default.
• W2080973344 hasBestOaLocation W20809733442 @default.
• W2080973344 hasConcept C104317684 @default.
• W2080973344 hasConcept C143065580 @default.
• W2080973344 hasConcept C20950039 @default.
• W2080973344 hasConcept C2778460671 @default.
• W2080973344 hasConcept C2779882130 @default.
• W2080973344 hasConcept C2780681812 @default.
• W2080973344 hasConcept C2781264208 @default.
• W2080973344 hasConcept C2781374117 @default.
• W2080973344 hasConcept C515207424 @default.
• W2080973344 hasConcept C54355233 @default.
• W2080973344 hasConcept C547475151 @default.
• W2080973344 hasConcept C55493867 @default.
• W2080973344 hasConcept C86803240 @default.
• W2080973344 hasConceptScore W2080973344C104317684 @default.
• W2080973344 hasConceptScore W2080973344C143065580 @default.
• W2080973344 hasConceptScore W2080973344C20950039 @default.
• W2080973344 hasConceptScore W2080973344C2778460671 @default.
• W2080973344 hasConceptScore W2080973344C2779882130 @default.
• W2080973344 hasConceptScore W2080973344C2780681812 @default.
• W2080973344 hasConceptScore W2080973344C2781264208 @default.
• W2080973344 hasConceptScore W2080973344C2781374117 @default.
• W2080973344 hasConceptScore W2080973344C515207424 @default.
• W2080973344 hasConceptScore W2080973344C54355233 @default.
• W2080973344 hasConceptScore W2080973344C547475151 @default.
• W2080973344 hasConceptScore W2080973344C55493867 @default.
• W2080973344 hasConceptScore W2080973344C86803240 @default.
• W2080973344 hasIssue "3" @default.
• W2080973344 hasLocation W20809733441 @default.
• W2080973344 hasLocation W20809733442 @default.
• W2080973344 hasLocation W20809733443 @default.
• W2080973344 hasLocation W20809733444 @default.
• W2080973344 hasOpenAccess W2080973344 @default.
• W2080973344 hasPrimaryLocation W20809733441 @default.
• W2080973344 hasRelatedWork W1605350099 @default.
• W2080973344 hasRelatedWork W1815827219 @default.
• W2080973344 hasRelatedWork W1973792708 @default.

• next