Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080973488> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2080973488 abstract "High doses of diazepam (10-20 mg/kg) were shown to reduce the volume of acute carrageenan-induced inflammatory paw edema in rats. This effect was not observed after adrenalectomy or long-term use of similar doses of diazepam. The present experiment was undertaken to analyze the effects of long-term (21 daily injections) treatment with diazepam (10 mg/kg) on both carrageenan-induced paw edema (CIPE) and corticosterone serum levels. For comparison, the effects of a single and acute 10 mg/kg dose of diazepam were also analyzed. Results showed that: 1- long-term diazepam treatment induced no changes in CIPE values and corticosterone serum levels; 2- acute diazepam treatment reduced CIPE values and increased corticosterone serum levels; 3- the plasmatic levels of diazepam measured 1 hour after the single treatment or 1 hour after the last dose of long-term diazepam administration were not different. These results indicate the development of tolerance to diazepam effects on both CIPE and corticosterone serum levels and suggest a relevant role for corticosterone on diazepam-induced inhibition of acute inflammation. Data were discussed in the light of peripheral benzodiazepine receptor site (PBR) activation within adrenal gland cells by diazepam, thereby increasing the serum levels of corticosterone and thus reducing CIPE. Possible actions of diazepam on HPA axis activity and/or on cytokine network were also discussed." @default.
- W2080973488 created "2016-06-24" @default.
- W2080973488 creator A5022624251 @default.
- W2080973488 creator A5037133546 @default.
- W2080973488 creator A5060879543 @default.
- W2080973488 creator A5076700857 @default.
- W2080973488 creator A5086165569 @default.
- W2080973488 date "2003-04-01" @default.
- W2080973488 modified "2023-10-16" @default.
- W2080973488 title "Reduction of inflammation in rats by diazepam: tolerance development" @default.
- W2080973488 cites W1823140459 @default.
- W2080973488 cites W1970815880 @default.
- W2080973488 cites W1970876497 @default.
- W2080973488 cites W1979577546 @default.
- W2080973488 cites W1993533965 @default.
- W2080973488 cites W1993826689 @default.
- W2080973488 cites W2024535965 @default.
- W2080973488 cites W2036370867 @default.
- W2080973488 cites W2059692874 @default.
- W2080973488 cites W2059817184 @default.
- W2080973488 cites W2060550948 @default.
- W2080973488 cites W2062333980 @default.
- W2080973488 cites W2062921245 @default.
- W2080973488 cites W2072875545 @default.
- W2080973488 cites W2082690640 @default.
- W2080973488 cites W2090514027 @default.
- W2080973488 cites W2094095364 @default.
- W2080973488 cites W2096357732 @default.
- W2080973488 cites W2126255384 @default.
- W2080973488 cites W2145493299 @default.
- W2080973488 cites W2195863613 @default.
- W2080973488 cites W2246502984 @default.
- W2080973488 cites W2259772202 @default.
- W2080973488 cites W2284353646 @default.
- W2080973488 cites W2429395267 @default.
- W2080973488 doi "https://doi.org/10.1016/s0024-3205(03)00136-x" @default.
- W2080973488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12639701" @default.
- W2080973488 hasPublicationYear "2003" @default.
- W2080973488 type Work @default.
- W2080973488 sameAs 2080973488 @default.
- W2080973488 citedByCount "31" @default.
- W2080973488 countsByYear W20809734882012 @default.
- W2080973488 countsByYear W20809734882015 @default.
- W2080973488 countsByYear W20809734882016 @default.
- W2080973488 countsByYear W20809734882017 @default.
- W2080973488 countsByYear W20809734882020 @default.
- W2080973488 crossrefType "journal-article" @default.
- W2080973488 hasAuthorship W2080973488A5022624251 @default.
- W2080973488 hasAuthorship W2080973488A5037133546 @default.
- W2080973488 hasAuthorship W2080973488A5060879543 @default.
- W2080973488 hasAuthorship W2080973488A5076700857 @default.
- W2080973488 hasAuthorship W2080973488A5086165569 @default.
- W2080973488 hasConcept C126322002 @default.
- W2080973488 hasConcept C134018914 @default.
- W2080973488 hasConcept C185592680 @default.
- W2080973488 hasConcept C2776175493 @default.
- W2080973488 hasConcept C2780352252 @default.
- W2080973488 hasConcept C71315377 @default.
- W2080973488 hasConcept C71924100 @default.
- W2080973488 hasConcept C98274493 @default.
- W2080973488 hasConceptScore W2080973488C126322002 @default.
- W2080973488 hasConceptScore W2080973488C134018914 @default.
- W2080973488 hasConceptScore W2080973488C185592680 @default.
- W2080973488 hasConceptScore W2080973488C2776175493 @default.
- W2080973488 hasConceptScore W2080973488C2780352252 @default.
- W2080973488 hasConceptScore W2080973488C71315377 @default.
- W2080973488 hasConceptScore W2080973488C71924100 @default.
- W2080973488 hasConceptScore W2080973488C98274493 @default.
- W2080973488 hasLocation W20809734881 @default.
- W2080973488 hasLocation W20809734882 @default.
- W2080973488 hasOpenAccess W2080973488 @default.
- W2080973488 hasPrimaryLocation W20809734881 @default.
- W2080973488 hasRelatedWork W1519074143 @default.
- W2080973488 hasRelatedWork W1537418123 @default.
- W2080973488 hasRelatedWork W1596638623 @default.
- W2080973488 hasRelatedWork W1970137563 @default.
- W2080973488 hasRelatedWork W1974672699 @default.
- W2080973488 hasRelatedWork W1975782468 @default.
- W2080973488 hasRelatedWork W1976007088 @default.
- W2080973488 hasRelatedWork W1979263239 @default.
- W2080973488 hasRelatedWork W1982904143 @default.
- W2080973488 hasRelatedWork W2034450620 @default.
- W2080973488 hasRelatedWork W2042349780 @default.
- W2080973488 hasRelatedWork W2042778729 @default.
- W2080973488 hasRelatedWork W2054337028 @default.
- W2080973488 hasRelatedWork W2062333980 @default.
- W2080973488 hasRelatedWork W2072875545 @default.
- W2080973488 hasRelatedWork W2075444377 @default.
- W2080973488 hasRelatedWork W2094095364 @default.
- W2080973488 hasRelatedWork W2126255384 @default.
- W2080973488 hasRelatedWork W2246502984 @default.
- W2080973488 hasRelatedWork W2259772202 @default.
- W2080973488 isParatext "false" @default.
- W2080973488 isRetracted "false" @default.
- W2080973488 magId "2080973488" @default.
- W2080973488 workType "article" @default.