Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080973723> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2080973723 endingPage "548" @default.
- W2080973723 startingPage "545" @default.
- W2080973723 abstract "Ingestion of 3-nitropropionic acid (3-NPA) in moldy sugar cane causes brain damage in children. The mechanism of 3-NPA toxicity is thought to be inhibition of energy production, leading to ATP depletion and excitotoxicity. We exposed cultured mouse striatal or cortical neurons to 1-2 mM 3-NPA for 48 h. This exposure produced gradual neuronal degeneration characterized by cell body shrinkage and DNA fragmentation. Addition of glutamate antagonists during 3-NPA exposure did not reduce neuronal death. However, addition of the macromolecular synthesis inhibitors cycloheximide, emetine or actinomycin D markedly reduced neuronal death. Our results do not exclude that 3-NPA can induce excitotoxicity in more intact systems, but raise the additional possibility that 3-NPA may also act to induce neuronal apoptosis." @default.
- W2080973723 created "2016-06-24" @default.
- W2080973723 creator A5005050761 @default.
- W2080973723 creator A5005398134 @default.
- W2080973723 creator A5024277256 @default.
- W2080973723 creator A5034268426 @default.
- W2080973723 creator A5040610824 @default.
- W2080973723 creator A5066110360 @default.
- W2080973723 date "1995-02-01" @default.
- W2080973723 modified "2023-10-17" @default.
- W2080973723 title "3-Nitropropionic acid induces apoptosis in cultured striatal and cortical neurons" @default.
- W2080973723 doi "https://doi.org/10.1097/00001756-199502000-00034" @default.
- W2080973723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7766861" @default.
- W2080973723 hasPublicationYear "1995" @default.
- W2080973723 type Work @default.
- W2080973723 sameAs 2080973723 @default.
- W2080973723 citedByCount "108" @default.
- W2080973723 countsByYear W20809737232012 @default.
- W2080973723 countsByYear W20809737232013 @default.
- W2080973723 countsByYear W20809737232014 @default.
- W2080973723 countsByYear W20809737232017 @default.
- W2080973723 countsByYear W20809737232018 @default.
- W2080973723 countsByYear W20809737232021 @default.
- W2080973723 crossrefType "journal-article" @default.
- W2080973723 hasAuthorship W2080973723A5005050761 @default.
- W2080973723 hasAuthorship W2080973723A5005398134 @default.
- W2080973723 hasAuthorship W2080973723A5024277256 @default.
- W2080973723 hasAuthorship W2080973723A5034268426 @default.
- W2080973723 hasAuthorship W2080973723A5040610824 @default.
- W2080973723 hasAuthorship W2080973723A5066110360 @default.
- W2080973723 hasConcept C169760540 @default.
- W2080973723 hasConcept C170493617 @default.
- W2080973723 hasConcept C178790620 @default.
- W2080973723 hasConcept C185592680 @default.
- W2080973723 hasConcept C190283241 @default.
- W2080973723 hasConcept C2778128677 @default.
- W2080973723 hasConcept C2778794669 @default.
- W2080973723 hasConcept C2780358027 @default.
- W2080973723 hasConcept C2781012912 @default.
- W2080973723 hasConcept C29730261 @default.
- W2080973723 hasConcept C31573885 @default.
- W2080973723 hasConcept C3675279 @default.
- W2080973723 hasConcept C55493867 @default.
- W2080973723 hasConcept C61174792 @default.
- W2080973723 hasConcept C86803240 @default.
- W2080973723 hasConcept C95444343 @default.
- W2080973723 hasConcept C98274493 @default.
- W2080973723 hasConceptScore W2080973723C169760540 @default.
- W2080973723 hasConceptScore W2080973723C170493617 @default.
- W2080973723 hasConceptScore W2080973723C178790620 @default.
- W2080973723 hasConceptScore W2080973723C185592680 @default.
- W2080973723 hasConceptScore W2080973723C190283241 @default.
- W2080973723 hasConceptScore W2080973723C2778128677 @default.
- W2080973723 hasConceptScore W2080973723C2778794669 @default.
- W2080973723 hasConceptScore W2080973723C2780358027 @default.
- W2080973723 hasConceptScore W2080973723C2781012912 @default.
- W2080973723 hasConceptScore W2080973723C29730261 @default.
- W2080973723 hasConceptScore W2080973723C31573885 @default.
- W2080973723 hasConceptScore W2080973723C3675279 @default.
- W2080973723 hasConceptScore W2080973723C55493867 @default.
- W2080973723 hasConceptScore W2080973723C61174792 @default.
- W2080973723 hasConceptScore W2080973723C86803240 @default.
- W2080973723 hasConceptScore W2080973723C95444343 @default.
- W2080973723 hasConceptScore W2080973723C98274493 @default.
- W2080973723 hasIssue "3" @default.
- W2080973723 hasLocation W20809737231 @default.
- W2080973723 hasLocation W20809737232 @default.
- W2080973723 hasOpenAccess W2080973723 @default.
- W2080973723 hasPrimaryLocation W20809737231 @default.
- W2080973723 hasRelatedWork W1995462121 @default.
- W2080973723 hasRelatedWork W1998846538 @default.
- W2080973723 hasRelatedWork W2002696533 @default.
- W2080973723 hasRelatedWork W2014080232 @default.
- W2080973723 hasRelatedWork W2061650382 @default.
- W2080973723 hasRelatedWork W2075333858 @default.
- W2080973723 hasRelatedWork W2080973723 @default.
- W2080973723 hasRelatedWork W2092116220 @default.
- W2080973723 hasRelatedWork W2095163420 @default.
- W2080973723 hasRelatedWork W2518781255 @default.
- W2080973723 hasVolume "6" @default.
- W2080973723 isParatext "false" @default.
- W2080973723 isRetracted "false" @default.
- W2080973723 magId "2080973723" @default.
- W2080973723 workType "article" @default.