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• W2080973779 abstract "Mice are excellent experimental models for genetic research and are being used to investigate the genetic component of organismal aging. Several mutant mice are known to possess defects in the growth hormone/insulin-like growth factor 1 (GH/IGF-1) neurohormonal pathway and exhibit dwarfism together with extended life span. Their phenotypes resemble those of mice subjected to caloric restriction. Targeted mutations that affect components of this pathway, including the GH receptor, p66Shc, and the IGF-1 receptor (IGF-1R), also extend life span; mutations that affect IGF-1R or downstream components of the pathway decouple longevity effects from dwarfism. These effects on life span may result from an increased capacity to resist oxidative damage." @default.
• W2080973779 created "2016-06-24" @default.
• W2080973779 creator A5028799700 @default.
• W2080973779 creator A5081300202 @default.
• W2080973779 date "2004-08-04" @default.
• W2080973779 modified "2023-10-15" @default.
• W2080973779 title "Murine Models of Life Span Extension" @default.
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