Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080974077> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2080974077 endingPage "140" @default.
- W2080974077 startingPage "125" @default.
- W2080974077 abstract "This paper deals with sources of uncertainty in the use of a minimal physiological toxicokinetic model to obtain dose estimates for a dose-response analysis of cancer in an occupational cohort. Toxicokinetic models make it possible to construct exposure parameters that are more closely related to the individual dose than traditional measures of exposures to toxic agents. However, the process introduces a wide array of sources of uncertainty. Selecting a model structure to describe the kinetics of a toxic agent implies necessarily making simplifications and assumptions that influence the range of applicability of the model. Once a model has been selected, the value of certain model parameters (constants) must be assigned, for example, from anthropometric data. The question then arises of how sensitive the model predictions are to variations in the values of these constants. Other model parameters, typically those describing the kinetics of the agent, are next estimated from actual data. There may be limitations in the data concerning, for example, sparseness (too few observations per subject) or missing values. The methods used for parameter estimation carry their own set of assumptions that need to be appropriate to the situation at hand. In summary, the dioxin example is used to characterize the sources of uncertainty at different levels, such as model structure, methods and data used for parameter estimation, estimation of occupational exposure, and imputation of missing values in exposure indices derived from the kinetic model." @default.
- W2080974077 created "2016-06-24" @default.
- W2080974077 creator A5019585002 @default.
- W2080974077 creator A5029279685 @default.
- W2080974077 creator A5048183904 @default.
- W2080974077 creator A5070538936 @default.
- W2080974077 date "1999-12-01" @default.
- W2080974077 modified "2023-09-25" @default.
- W2080974077 title "Uncertainty in Estimating Exposure Using a Toxicokinetic Model: The Example of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin" @default.
- W2080974077 cites W1900651926 @default.
- W2080974077 cites W1983185789 @default.
- W2080974077 cites W1995349067 @default.
- W2080974077 cites W1999493231 @default.
- W2080974077 cites W2005769414 @default.
- W2080974077 cites W2012259311 @default.
- W2080974077 cites W2026599052 @default.
- W2080974077 cites W2033661476 @default.
- W2080974077 cites W2044056030 @default.
- W2080974077 cites W2058551853 @default.
- W2080974077 cites W2066554268 @default.
- W2080974077 cites W2068973221 @default.
- W2080974077 cites W2088301481 @default.
- W2080974077 cites W2108802321 @default.
- W2080974077 cites W2118502261 @default.
- W2080974077 cites W2130416410 @default.
- W2080974077 cites W2334532617 @default.
- W2080974077 cites W245479767 @default.
- W2080974077 cites W2797508167 @default.
- W2080974077 cites W4247627760 @default.
- W2080974077 cites W4300187280 @default.
- W2080974077 doi "https://doi.org/10.1111/j.1749-6632.1999.tb08081.x" @default.
- W2080974077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10676413" @default.
- W2080974077 hasPublicationYear "1999" @default.
- W2080974077 type Work @default.
- W2080974077 sameAs 2080974077 @default.
- W2080974077 citedByCount "2" @default.
- W2080974077 crossrefType "journal-article" @default.
- W2080974077 hasAuthorship W2080974077A5019585002 @default.
- W2080974077 hasAuthorship W2080974077A5029279685 @default.
- W2080974077 hasAuthorship W2080974077A5048183904 @default.
- W2080974077 hasAuthorship W2080974077A5070538936 @default.
- W2080974077 hasConcept C105795698 @default.
- W2080974077 hasConcept C127413603 @default.
- W2080974077 hasConcept C146978453 @default.
- W2080974077 hasConcept C149782125 @default.
- W2080974077 hasConcept C177264268 @default.
- W2080974077 hasConcept C178790620 @default.
- W2080974077 hasConcept C185592680 @default.
- W2080974077 hasConcept C195289149 @default.
- W2080974077 hasConcept C199360897 @default.
- W2080974077 hasConcept C204323151 @default.
- W2080974077 hasConcept C29730261 @default.
- W2080974077 hasConcept C33923547 @default.
- W2080974077 hasConcept C41008148 @default.
- W2080974077 hasConcept C55037315 @default.
- W2080974077 hasConcept C58489278 @default.
- W2080974077 hasConceptScore W2080974077C105795698 @default.
- W2080974077 hasConceptScore W2080974077C127413603 @default.
- W2080974077 hasConceptScore W2080974077C146978453 @default.
- W2080974077 hasConceptScore W2080974077C149782125 @default.
- W2080974077 hasConceptScore W2080974077C177264268 @default.
- W2080974077 hasConceptScore W2080974077C178790620 @default.
- W2080974077 hasConceptScore W2080974077C185592680 @default.
- W2080974077 hasConceptScore W2080974077C195289149 @default.
- W2080974077 hasConceptScore W2080974077C199360897 @default.
- W2080974077 hasConceptScore W2080974077C204323151 @default.
- W2080974077 hasConceptScore W2080974077C29730261 @default.
- W2080974077 hasConceptScore W2080974077C33923547 @default.
- W2080974077 hasConceptScore W2080974077C41008148 @default.
- W2080974077 hasConceptScore W2080974077C55037315 @default.
- W2080974077 hasConceptScore W2080974077C58489278 @default.
- W2080974077 hasIssue "1 UNCERTAINTY I" @default.
- W2080974077 hasLocation W20809740771 @default.
- W2080974077 hasLocation W20809740772 @default.
- W2080974077 hasOpenAccess W2080974077 @default.
- W2080974077 hasPrimaryLocation W20809740771 @default.
- W2080974077 hasRelatedWork W2026453598 @default.
- W2080974077 hasRelatedWork W2027108423 @default.
- W2080974077 hasRelatedWork W2117904580 @default.
- W2080974077 hasRelatedWork W2119158312 @default.
- W2080974077 hasRelatedWork W2153913439 @default.
- W2080974077 hasRelatedWork W2355215981 @default.
- W2080974077 hasRelatedWork W2552050053 @default.
- W2080974077 hasRelatedWork W2980908687 @default.
- W2080974077 hasRelatedWork W3189969450 @default.
- W2080974077 hasRelatedWork W4235907884 @default.
- W2080974077 hasVolume "895" @default.
- W2080974077 isParatext "false" @default.
- W2080974077 isRetracted "false" @default.
- W2080974077 magId "2080974077" @default.
- W2080974077 workType "article" @default.