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- W2080974310 abstract "It is widely accepted that the polypoid adenoma is the precursor of colonic adenocarcinoma. 1 Morson BC Precancerous and early malignant lesions of the large intestine. Br J Surg. 1968; 55: 725-731 Crossref PubMed Scopus (183) Google Scholar , 2 Muto T Bussey HJR Morson BC The evolution of cancer of the colon and rectum. Cancer. 1975; 36: 2251-2270 Crossref PubMed Scopus (1911) Google Scholar , 3 Lane N The precursor tissue of ordinary large bowel cancer. Cancer Res. 1976; 36: 2669-2672 PubMed Google Scholar , 4 Fenoglio CM Lane N The anatomical precursor of colorectal carcinoma. Cancer. 1974; 34: 819-823 Crossref PubMed Scopus (133) Google Scholar Known as the adenoma-carcinoma sequence, this concept represents the development of colorectal cancer as an orderly sequence of events in which the small adenoma is the benign early stage. Over the course of a number of years, some benign adenomas gradually develop characteristics of malignancy as they increase in size. At some point, thought to be a number of years after its appearance, the formerly benign adenoma will have become a malignant tumor. Implicit to this concept are two fundamental premises: that the risk of malignancy increases as the adenoma increases in size, and that this size-malignancy transformation requires a relatively long period of time." @default.
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- W2080974310 date "1995-08-01" @default.
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- W2080974310 title "Flat adenomas and cancers" @default.
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- W2080974310 doi "https://doi.org/10.1016/s0016-5107(95)70081-1" @default.
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