FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080976720> ?p ?o ?g. }

• W2080976720 endingPage "3203" @default.
• W2080976720 startingPage "3202" @default.
• W2080976720 abstract "The immunosuppressive properties of azathioprine and 6-mercaptopurine are mediated by their active metabolite 6-thioguanine. Cuffari and colleagues performed a prospective study to determine the relationship of erythrocyte 6-thioguanine levels and treatment efficacy in adult patients with inflammatory disease (IBD). The study design is summarized in Figure 1 . Figure 1 Study design. AZA = azathioprine; 6-MP = 6-mercaptopurine. Eighty-two patients (42 females) with IBD aged 17–77 yr (mean age = 42) were studied. Among 63 with Crohn’s disease (CD) 29 had ileocolonic disease (15 with previous bowel resection) and 26 had colonic disease (four with previous resection). Twelve of the 19 with ulcerative colitis (UC) had pancolitis and the rest had left-sided disease. The mean duration of IBD was 6.3 yr, and 72 patients were on 5-aminosalicylate. In patients with CD, activity was measured using the Harvey-Bradshaw index and for UC a clinical activity score was adapted to monitor response to therapy. Remission was defined as an HBI score of <5 in those who were weaned off on <20 mg/alternate day of prednisolone or 3 mg/alternate day of budesonide. Daily azathioprine of 1–1.5 mg/kg or an equivalent dose of 6-mercaptopurine was started on each patient. The levels of 6-thioguanine metabolites were measured while one was on treatment for at least 12 wk. The erythrocyte 6-thioguanine level was measured by reverse phase high performance liquid chromatography. Thirty-three patients with CD and 14 with UC achieved remission at an average daily dose of 1.44 mg of azathioprine or 1.16 mg of 6-mercaptopurine. The median 6-thioguanine level for CD patients in remission was 316 pmol/8 × 10 8 red blood cells (RBCs), compared with 176 pmol/8 × 10 8 RBCs in those with incomplete responses. A significantly higher number of patients who responded to therapy had 6-thioguanine levels of >250 pmol/8 × 10 8 RBCs relative to those who failed to achieve remission. Treatment efficacy correlated with a 6-thioguanine level of >250 pmol/8 × 10 8 RBCs in patients with colonic and fistulating CD, but not in those with ileocolonic CD. Twenty-two out of 30 patients with CD who were incompletely responsive and had 6-thioguanine levels below 250 pmol/8 × 10 8 RBCs were recruited to the dose optimization study. The dose of azathioprine was increased by 25 mg/day at 8-wk intervals up to a median dose of 1.5 mg/kg/day. This was associated with a rise in the median 6-thioguanine level to 303 pmol/8 × 10 8 RBCs. Eighteen out of 22 patients achieved remission on this regime. The authors conclude that serial measurements of 6-thioguanine levels would be useful in optimizing azathioprine treatment without inducing leucopenia. Patients who were unresponsive to therapy despite adequate 6-thioguanine levels (>250 pmol/8 × 10 8 RBCs) should be considered refractory to azathioprine/6-mercaptopurine and offered other forms of treatment." @default.
• W2080976720 created "2016-06-24" @default.
• W2080976720 creator A5061651350 @default.
• W2080976720 creator A5064261646 @default.
• W2080976720 date "2001-11-01" @default.
• W2080976720 modified "2023-09-27" @default.
• W2080976720 title "Steering azathioprine safely: lessons from pharmacogenetics Cuffari C, Hunt S, Bayless T, Utilisation of Erythrocyte 6-Thioguanine Metabolite Levels to Optimise Azathioprine Therapy in Patients With Inflammatory Bowel Disease, Gut 2001;48:642–6" @default.
• W2080976720 cites W1996409190 @default.
• W2080976720 cites W2024293518 @default.
• W2080976720 cites W2058710761 @default.
• W2080976720 cites W2093793436 @default.
• W2080976720 cites W2145648574 @default.
• W2080976720 cites W3025531431 @default.
• W2080976720 doi "https://doi.org/10.1016/s0002-9270(01)03873-4" @default.
• W2080976720 hasPublicationYear "2001" @default.
• W2080976720 type Work @default.
• W2080976720 sameAs 2080976720 @default.
• W2080976720 citedByCount "2" @default.
• W2080976720 crossrefType "journal-article" @default.
• W2080976720 hasAuthorship W2080976720A5061651350 @default.
• W2080976720 hasAuthorship W2080976720A5064261646 @default.
• W2080976720 hasConcept C126322002 @default.
• W2080976720 hasConcept C141071460 @default.
• W2080976720 hasConcept C2776760755 @default.
• W2080976720 hasConcept C2777173762 @default.
• W2080976720 hasConcept C2777477808 @default.
• W2080976720 hasConcept C2778260677 @default.
• W2080976720 hasConcept C2779134260 @default.
• W2080976720 hasConcept C2780479503 @default.
• W2080976720 hasConcept C70917649 @default.
• W2080976720 hasConcept C71924100 @default.
• W2080976720 hasConcept C90924648 @default.
• W2080976720 hasConceptScore W2080976720C126322002 @default.
• W2080976720 hasConceptScore W2080976720C141071460 @default.
• W2080976720 hasConceptScore W2080976720C2776760755 @default.
• W2080976720 hasConceptScore W2080976720C2777173762 @default.
• W2080976720 hasConceptScore W2080976720C2777477808 @default.
• W2080976720 hasConceptScore W2080976720C2778260677 @default.
• W2080976720 hasConceptScore W2080976720C2779134260 @default.
• W2080976720 hasConceptScore W2080976720C2780479503 @default.
• W2080976720 hasConceptScore W2080976720C70917649 @default.
• W2080976720 hasConceptScore W2080976720C71924100 @default.
• W2080976720 hasConceptScore W2080976720C90924648 @default.
• W2080976720 hasIssue "11" @default.
• W2080976720 hasLocation W20809767201 @default.
• W2080976720 hasOpenAccess W2080976720 @default.
• W2080976720 hasPrimaryLocation W20809767201 @default.
• W2080976720 hasRelatedWork W1938456082 @default.
• W2080976720 hasRelatedWork W1967287887 @default.
• W2080976720 hasRelatedWork W1968809716 @default.
• W2080976720 hasRelatedWork W1985852719 @default.
• W2080976720 hasRelatedWork W2017131874 @default.
• W2080976720 hasRelatedWork W2030477288 @default.
• W2080976720 hasRelatedWork W2034081736 @default.
• W2080976720 hasRelatedWork W2040181440 @default.
• W2080976720 hasRelatedWork W2091723701 @default.
• W2080976720 hasRelatedWork W2101453034 @default.
• W2080976720 hasRelatedWork W2102457440 @default.
• W2080976720 hasRelatedWork W2322180153 @default.
• W2080976720 hasRelatedWork W2407725948 @default.
• W2080976720 hasRelatedWork W2549444082 @default.
• W2080976720 hasRelatedWork W2793469548 @default.
• W2080976720 hasRelatedWork W3022454465 @default.
• W2080976720 hasRelatedWork W3029424693 @default.
• W2080976720 hasRelatedWork W3102999053 @default.
• W2080976720 hasRelatedWork W2186518177 @default.
• W2080976720 hasRelatedWork W2595447270 @default.
• W2080976720 hasVolume "96" @default.
• W2080976720 isParatext "false" @default.
• W2080976720 isRetracted "false" @default.
• W2080976720 magId "2080976720" @default.
• W2080976720 workType "article" @default.