FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080977462> ?p ?o ?g. }

• W2080977462 endingPage "1096" @default.
• W2080977462 startingPage "1089" @default.
• W2080977462 abstract "Cytotoxic T lymphocytes (CTL) play an important role in limiting viral infections and in eradicating virus from host tissues. Recent progress in understanding the processing and presentation of viral antigens to CTL indicates that the CTL antigen receptor recognizes peptides derived from viral proteins that are bound to an antigen binding groove present in class I major histocompatibility complex (MHC) molecules. In understanding CTL anti-viral responses and in creating vaccines designed to elicit CTL responses, it is critical to identify the portions of viral proteins that bind class I molecules and are recognized by T cell receptors. Previous findings have indicated that a significant portion of the CTL response of H-2d mice to influenza virus is specific for one of the viral polymerases (PB2). To identify the region of PB2 naturally processed and presented by influenza virusinfected mouse cells to CTL, 31 PB2 peptides of 9–16 residues in length were chosen and chemically synthesized. Two peptides, PB2, residues 146–159 and 187–195, were found to sensitize histocompatible target cells for recognition by influenza virus-specific CTL. When CTL were generated to individual viral proteins using influenza-vaccinia recombinant viruses, we found, to our surprise, that PB2-specific CTL failed to recognize cells sensitized with PB2 peptides 146–159 and 187–195. Further analysis showed that these PB2 peptides were, in fact, recognized by nucleoprotein (NP)-specific CTL generated by NP-vac virus priming and influenza A virus stimulation, or NP peptide stimulation in vitro of NP-vac or influenza A-primed CTL. These results demonstrate that while screening peptide libraries one cannot assume that positive peptides necessarily identify the viral protein to which the CTL response is directed." @default.
• W2080977462 created "2016-06-24" @default.
• W2080977462 creator A5030635221 @default.
• W2080977462 creator A5062037076 @default.
• W2080977462 creator A5070440610 @default.
• W2080977462 creator A5071953402 @default.
• W2080977462 creator A5089360403 @default.
• W2080977462 date "1992-09-01" @default.
• W2080977462 modified "2023-09-28" @default.
• W2080977462 title "Influenza basic polymerase 2 peptides are recognized by influenza nucleoprotein-specific cytotoxic T lymphocytes" @default.
• W2080977462 cites W1511305125 @default.
• W2080977462 cites W153972386 @default.
• W2080977462 cites W1623962303 @default.
• W2080977462 cites W1856760175 @default.
• W2080977462 cites W1955772696 @default.
• W2080977462 cites W1967852878 @default.
• W2080977462 cites W1968800495 @default.
• W2080977462 cites W1972235351 @default.
• W2080977462 cites W1980897291 @default.
• W2080977462 cites W1981961617 @default.
• W2080977462 cites W1990137584 @default.
• W2080977462 cites W1990806106 @default.
• W2080977462 cites W1992412976 @default.
• W2080977462 cites W1995317534 @default.
• W2080977462 cites W2009115410 @default.
• W2080977462 cites W2011148276 @default.
• W2080977462 cites W2014916785 @default.
• W2080977462 cites W2022717713 @default.
• W2080977462 cites W2034868125 @default.
• W2080977462 cites W2035471910 @default.
• W2080977462 cites W2043120431 @default.
• W2080977462 cites W2044630649 @default.
• W2080977462 cites W2048310562 @default.
• W2080977462 cites W2055220017 @default.
• W2080977462 cites W2063841466 @default.
• W2080977462 cites W2080757497 @default.
• W2080977462 cites W2085147318 @default.
• W2080977462 cites W2096273252 @default.
• W2080977462 cites W2111441225 @default.
• W2080977462 cites W2136850348 @default.
• W2080977462 cites W2146581768 @default.
• W2080977462 cites W2162336526 @default.
• W2080977462 doi "https://doi.org/10.1016/0161-5890(92)90041-u" @default.
• W2080977462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1495499" @default.
• W2080977462 hasPublicationYear "1992" @default.
• W2080977462 type Work @default.
• W2080977462 sameAs 2080977462 @default.
• W2080977462 citedByCount "35" @default.
• W2080977462 countsByYear W20809774622013 @default.
• W2080977462 countsByYear W20809774622014 @default.
• W2080977462 countsByYear W20809774622015 @default.
• W2080977462 countsByYear W20809774622016 @default.
• W2080977462 crossrefType "journal-article" @default.
• W2080977462 hasAuthorship W2080977462A5030635221 @default.
• W2080977462 hasAuthorship W2080977462A5062037076 @default.
• W2080977462 hasAuthorship W2080977462A5070440610 @default.
• W2080977462 hasAuthorship W2080977462A5071953402 @default.
• W2080977462 hasAuthorship W2080977462A5089360403 @default.
• W2080977462 hasConcept C147483822 @default.
• W2080977462 hasConcept C147969180 @default.
• W2080977462 hasConcept C154317977 @default.
• W2080977462 hasConcept C159047783 @default.
• W2080977462 hasConcept C170627219 @default.
• W2080977462 hasConcept C202751555 @default.
• W2080977462 hasConcept C203014093 @default.
• W2080977462 hasConcept C207936829 @default.
• W2080977462 hasConcept C2522874641 @default.
• W2080977462 hasConcept C2777546802 @default.
• W2080977462 hasConcept C2781416681 @default.
• W2080977462 hasConcept C55493867 @default.
• W2080977462 hasConcept C60325843 @default.
• W2080977462 hasConcept C86803240 @default.
• W2080977462 hasConceptScore W2080977462C147483822 @default.
• W2080977462 hasConceptScore W2080977462C147969180 @default.
• W2080977462 hasConceptScore W2080977462C154317977 @default.
• W2080977462 hasConceptScore W2080977462C159047783 @default.
• W2080977462 hasConceptScore W2080977462C170627219 @default.
• W2080977462 hasConceptScore W2080977462C202751555 @default.
• W2080977462 hasConceptScore W2080977462C203014093 @default.
• W2080977462 hasConceptScore W2080977462C207936829 @default.
• W2080977462 hasConceptScore W2080977462C2522874641 @default.
• W2080977462 hasConceptScore W2080977462C2777546802 @default.
• W2080977462 hasConceptScore W2080977462C2781416681 @default.
• W2080977462 hasConceptScore W2080977462C55493867 @default.
• W2080977462 hasConceptScore W2080977462C60325843 @default.
• W2080977462 hasConceptScore W2080977462C86803240 @default.
• W2080977462 hasIssue "9" @default.
• W2080977462 hasLocation W20809774621 @default.
• W2080977462 hasLocation W20809774622 @default.
• W2080977462 hasOpenAccess W2080977462 @default.
• W2080977462 hasPrimaryLocation W20809774621 @default.
• W2080977462 hasRelatedWork W1981366552 @default.
• W2080977462 hasRelatedWork W1989353793 @default.
• W2080977462 hasRelatedWork W2052483994 @default.
• W2080977462 hasRelatedWork W2069658208 @default.
• W2080977462 hasRelatedWork W2100196824 @default.
• W2080977462 hasRelatedWork W2142016985 @default.
• W2080977462 hasRelatedWork W2147629250 @default.

• next