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• W2080980905 abstract "Significance Proper recruitment of inhibitory interneurons is crucial to configuring cortical neural circuits for information processing and propagation, but the development of synaptic inputs to these interneurons is not well-understood. We traced the sources of long-range and local inputs to a major interneuron subtype, the parvalbumin-positive interneurons (PVNs), in mouse visual cortex. Whereas the long-range inputs show strong short-term synaptic depression, local recurrent inputs gradually lose such depression during postnatal maturation. We further uncovered the circuitry and molecular mechanisms that contribute to this source-dependent maturation in synaptic inputs. Although short-term depression of long-range inputs is well-suited for afferent signal detection, the robust synaptic dynamics of local inputs may facilitate rapid and proportional PVN recruitment for regulating network operations." @default.
• W2080980905 created "2016-06-24" @default.
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• W2080980905 date "2014-11-10" @default.
• W2080980905 modified "2023-09-30" @default.
• W2080980905 title "Input-specific maturation of synaptic dynamics of parvalbumin interneurons in primary visual cortex" @default.
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• W2080980905 doi "https://doi.org/10.1073/pnas.1400694111" @default.
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