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• W2080987308 abstract "The anti-estrogens CI-628 (CI) and enclomiphene (ENC) were used to antagonize the estrogen-induced sexual behavior of female guinea pigs. Full receptivity was activated in 96% of ovariectomized control guinea pigs given 1.6 μg estradiol benzoate (EB) and then injected with 0.5 mg progesterone (P) 39 h later. In experiment 1, the ability of EB to induce lordosis was not blocked when CI (2 mg) or ENC (5 and 20 mg) was administered either concurrently with EB or within 2 h of the EB injection. However, in experiment 2, extensive pretreatment with ENC (5 mg/injection) at 48, 24, 12, and 0 h before the start of the 39 h EB priming period significantly decreased (to 50%) the percentage of animals displaying lordosis. Similar pretreatment with CI (2 mg/injection) had no inhibitory effects on lordosis. Experiments 3 and 4 evaluated the ability of CI, ENC, and zuclomiphene (ZUC) to induce sexual behavior in ovariectomized guinea pigs. In experiment 3, guinea pigs were injected 3 times with CI (2 mg/injection), ENC or ZUC (5 mg/injection) over a 39 h interval and then injected with P. No anti-estrogen was able to induce lordosis in this situation. Experiment 4 assessed the ability of CI, ENC, or ZUC to facilitate the action of EB on sexual behavior. For this study the EB priming period was shortened from 39 h to 11 h. This resulted in a significant decrease in the percentage of animals displaying lordosis (controls= 15%of animals receptive). Administration of ENC (10 mg) 28 h prior to the 11 h of EB priming significantly facilitated the incidence of receptivity (62% of animals receptive). Similar administration of ZUC (10 mg) produced a slight but non-significant facilitation (37% of animals receptive) while CI (4 mg) had no facilitatory effects7 (0% receptive). The results obtained in these experiments using a manual stimulation technique for elicitation of lordosis were replicated by using a male. In all cases tested, treatment that induced lordosis to manual stimulation also facilitated receptivity to a male. These results indicate that CI and ENC do not as readily inhibit the action of EB priming in guinea pigs as they do in rats. Further, it appears that ENC can mimic at least some of the early effects of EB priming. However, the presence of estrogen is necessary in the later portion of the priming period for the expression of lordosis." @default.
• W2080987308 created "2016-06-24" @default.
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• W2080987308 date "1977-10-01" @default.
• W2080987308 modified "2023-09-27" @default.
• W2080987308 title "Inhibitory and facilitatory effects of various anti-estrogens on the induction of female sexual behavior by estradiol benzoate in guinea pigs" @default.
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• W2080987308 doi "https://doi.org/10.1016/0006-8993(77)90822-8" @default.
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