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• W2080990568 abstract "Pseudomonas putida F1 is unable to grow on styrene due to the accumulation of 3-vinylcatechol, a toxic metabolite that is produced through the toluene degradation (tod) pathway and causes catechol-2,3-dioxygenase (C23O) inactivation. In this study, we characterized a spontaneous F1 mutant, designated SF1, which acquired the ability to grow on styrene and did not accumulate 3-vinylcatechol. Whereas adaptation to new aromatic substrates has typically been shown to involve increased C23O activity or the acquisition of resistance to C23O inactivation, SF1 retained wild-type C23O activity. Surprisingly, SF1 grew more slowly on toluene, its native substrate, and exhibited reduced toluene dioxygenase (TDO) activity (approximately 50 % of that of F1), the enzyme responsible for ring hydroxylation and subsequent production of 3-vinylcatechol. DNA sequence analysis of the tod operon of SF1 revealed a single base pair mutation in todA (C479T), a gene encoding the reductase component of TDO. Replacement of the wild-type todA allele in F1 with todA C479T reduced TDO activity to SF1 levels, obviated vinylcatechol accumulation, and conferred the ability to grow on styrene. This novel ‘less is more’ strategy – reduced catechol production as a means to expand growth substrate range – sheds light on an alternative approach for managing catechol toxicity during the metabolism of aromatic compounds." @default.
• W2080990568 created "2016-06-24" @default.
• W2080990568 creator A5000536603 @default.
• W2080990568 creator A5083866127 @default.
• W2080990568 date "2012-11-01" @default.
• W2080990568 modified "2023-10-18" @default.
• W2080990568 title "Less is more: reduced catechol production permits Pseudomonas putida F1 to grow on styrene" @default.
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• W2080990568 doi "https://doi.org/10.1099/mic.0.058230-0" @default.
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