Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080995509> ?p ?o ?g. }
- W2080995509 endingPage "220" @default.
- W2080995509 startingPage "215" @default.
- W2080995509 abstract "Quercetin (QT) could be considered as a potential therapeutic agent for different diseases due to its antioxidant, anti-inflammatory, antiviral and anticancer properties. This study was designed to investigate the ability of QT to protect the chick intestine against menadione (MEN) induced injury in vivo and in vitro. Four-week old chicks (Gallus gallus) were treated i.p. with 2.5μmol of MEN/kg b.w. or with i.l. 50μM QT or both. QT protected the intestinal Ca(2+) absorption against the inhibition caused by MEN, but QT alone did not modify. Glutathione (GSH) depletion provoked by MEN in chick enterocytes was abolished by QT treatment, whereas QT alone did not modify the intestinal GSH content. The enhancement of GSH peroxidase activity produced by MEN was blocked by QT treatment. In contrast, superoxide dismutase activity remained high after simultaneous treatment of enterocytes with MEN and QT. The flavonol also avoided changes in the mitochondrial membrane permeability (swelling) produced by MEN. The FasL/Fas/caspase-3 pathway was activated by MEN, effect that was abrogated by QT. In conclusion, QT may be useful in preventing inhibition of chick intestinal Ca(2+) absorption caused by MEN or other substances that deplete GSH, by blocking the oxidative stress and the FasL/Fas/caspase-3 pathway activation." @default.
- W2080995509 created "2016-06-24" @default.
- W2080995509 creator A5024144490 @default.
- W2080995509 creator A5074328725 @default.
- W2080995509 creator A5090380227 @default.
- W2080995509 date "2013-01-01" @default.
- W2080995509 modified "2023-10-16" @default.
- W2080995509 title "Effects of quercetin and menadione on intestinal calcium absorption and the underlying mechanisms" @default.
- W2080995509 cites W1505511924 @default.
- W2080995509 cites W1506043065 @default.
- W2080995509 cites W1912855510 @default.
- W2080995509 cites W1918054424 @default.
- W2080995509 cites W1967692894 @default.
- W2080995509 cites W1973007305 @default.
- W2080995509 cites W1981969869 @default.
- W2080995509 cites W1983341578 @default.
- W2080995509 cites W1991614634 @default.
- W2080995509 cites W1996417742 @default.
- W2080995509 cites W1999635152 @default.
- W2080995509 cites W2003271687 @default.
- W2080995509 cites W2019044344 @default.
- W2080995509 cites W2024067398 @default.
- W2080995509 cites W2029044946 @default.
- W2080995509 cites W2041395936 @default.
- W2080995509 cites W2052152794 @default.
- W2080995509 cites W2054260525 @default.
- W2080995509 cites W2056170432 @default.
- W2080995509 cites W2060560143 @default.
- W2080995509 cites W2060560496 @default.
- W2080995509 cites W2067434070 @default.
- W2080995509 cites W2071239471 @default.
- W2080995509 cites W2074603384 @default.
- W2080995509 cites W2075976369 @default.
- W2080995509 cites W2077875611 @default.
- W2080995509 cites W2081261024 @default.
- W2080995509 cites W2082882269 @default.
- W2080995509 cites W2084775599 @default.
- W2080995509 cites W2099865369 @default.
- W2080995509 cites W2100837269 @default.
- W2080995509 cites W2101108802 @default.
- W2080995509 cites W2103450249 @default.
- W2080995509 cites W2103966440 @default.
- W2080995509 cites W2104487496 @default.
- W2080995509 cites W2113313289 @default.
- W2080995509 cites W2127181172 @default.
- W2080995509 cites W2129712974 @default.
- W2080995509 cites W2147993424 @default.
- W2080995509 cites W2162518284 @default.
- W2080995509 cites W2168502804 @default.
- W2080995509 cites W2169658899 @default.
- W2080995509 cites W4231042001 @default.
- W2080995509 cites W758260955 @default.
- W2080995509 doi "https://doi.org/10.1016/j.cbpa.2012.09.007" @default.
- W2080995509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23000882" @default.
- W2080995509 hasPublicationYear "2013" @default.
- W2080995509 type Work @default.
- W2080995509 sameAs 2080995509 @default.
- W2080995509 citedByCount "18" @default.
- W2080995509 countsByYear W20809955092013 @default.
- W2080995509 countsByYear W20809955092015 @default.
- W2080995509 countsByYear W20809955092017 @default.
- W2080995509 countsByYear W20809955092018 @default.
- W2080995509 countsByYear W20809955092019 @default.
- W2080995509 countsByYear W20809955092020 @default.
- W2080995509 countsByYear W20809955092021 @default.
- W2080995509 countsByYear W20809955092022 @default.
- W2080995509 crossrefType "journal-article" @default.
- W2080995509 hasAuthorship W2080995509A5024144490 @default.
- W2080995509 hasAuthorship W2080995509A5074328725 @default.
- W2080995509 hasAuthorship W2080995509A5090380227 @default.
- W2080995509 hasConcept C126322002 @default.
- W2080995509 hasConcept C134018914 @default.
- W2080995509 hasConcept C181199279 @default.
- W2080995509 hasConcept C185592680 @default.
- W2080995509 hasConcept C2775838275 @default.
- W2080995509 hasConcept C2776151105 @default.
- W2080995509 hasConcept C2778004101 @default.
- W2080995509 hasConcept C2778760513 @default.
- W2080995509 hasConcept C2781095387 @default.
- W2080995509 hasConcept C538909803 @default.
- W2080995509 hasConcept C55493867 @default.
- W2080995509 hasConcept C71924100 @default.
- W2080995509 hasConcept C86803240 @default.
- W2080995509 hasConcept C98274493 @default.
- W2080995509 hasConceptScore W2080995509C126322002 @default.
- W2080995509 hasConceptScore W2080995509C134018914 @default.
- W2080995509 hasConceptScore W2080995509C181199279 @default.
- W2080995509 hasConceptScore W2080995509C185592680 @default.
- W2080995509 hasConceptScore W2080995509C2775838275 @default.
- W2080995509 hasConceptScore W2080995509C2776151105 @default.
- W2080995509 hasConceptScore W2080995509C2778004101 @default.
- W2080995509 hasConceptScore W2080995509C2778760513 @default.
- W2080995509 hasConceptScore W2080995509C2781095387 @default.
- W2080995509 hasConceptScore W2080995509C538909803 @default.
- W2080995509 hasConceptScore W2080995509C55493867 @default.
- W2080995509 hasConceptScore W2080995509C71924100 @default.
- W2080995509 hasConceptScore W2080995509C86803240 @default.
- W2080995509 hasConceptScore W2080995509C98274493 @default.