Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080996925> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2080996925 abstract "The action of choline on maxi Ca(2+)-activated K+ channels was studied in excised patches of bovine chromaffin cell membranes. Choline (20-70 mM) applied to the internal surface of the membrane reduced the single channel current amplitudes, which can be explained by a fast channel block. The block is concentration- and voltage-dependent and is rapidly and completely reversed upon washout. The block becomes progressively greater with depolarization. The estimates of blocking parameters vary from channel to channel but appear to fall in two groups. A larger group (two-thirds of cases) with moderate affinity [KD(0) = 88.5 mM] and low voltage dependence (delta = 0.26) and a smaller group (one-third of cases) with very low affinity (KD = 306 mM) and moderate voltage dependence (delta = 0.59). The open state probability appears not to be affected at any choline concentration (up to 70 mM) or membrane potential (from -20 to +60 mV) studied, suggesting that choline does not affect the channel gating kinetics. Since the affinity of the choline block is low to moderate, the intracellular choline is not expected to alter the current flow through maxi Ca(2+)-activated K+ channels unless the choline concentration close to the protoplasmic membrane is much higher than the mean cellular concentration." @default.
- W2080996925 created "2016-06-24" @default.
- W2080996925 creator A5032537823 @default.
- W2080996925 creator A5044456642 @default.
- W2080996925 creator A5047690493 @default.
- W2080996925 date "1992-08-01" @default.
- W2080996925 modified "2023-09-27" @default.
- W2080996925 title "Choline blockage of currents through Ca2+-activated K+ channels in bovine chromaffin cells" @default.
- W2080996925 cites W1482790727 @default.
- W2080996925 cites W1521063903 @default.
- W2080996925 cites W1546904687 @default.
- W2080996925 cites W17369517 @default.
- W2080996925 cites W1812214972 @default.
- W2080996925 cites W1969581869 @default.
- W2080996925 cites W1972246035 @default.
- W2080996925 cites W1976430210 @default.
- W2080996925 cites W1979420766 @default.
- W2080996925 cites W1994279940 @default.
- W2080996925 cites W1996888692 @default.
- W2080996925 cites W2004079359 @default.
- W2080996925 cites W2009667219 @default.
- W2080996925 cites W2020949479 @default.
- W2080996925 cites W2025928186 @default.
- W2080996925 cites W2031932032 @default.
- W2080996925 cites W2033817793 @default.
- W2080996925 cites W2040648798 @default.
- W2080996925 cites W2056552455 @default.
- W2080996925 cites W2065320699 @default.
- W2080996925 cites W2070740805 @default.
- W2080996925 cites W2083654094 @default.
- W2080996925 cites W2119397841 @default.
- W2080996925 cites W2123146696 @default.
- W2080996925 cites W2133464980 @default.
- W2080996925 cites W2137628065 @default.
- W2080996925 cites W2139714561 @default.
- W2080996925 cites W2146152598 @default.
- W2080996925 doi "https://doi.org/10.1016/0306-4522(92)90370-h" @default.
- W2080996925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1436489" @default.
- W2080996925 hasPublicationYear "1992" @default.
- W2080996925 type Work @default.
- W2080996925 sameAs 2080996925 @default.
- W2080996925 citedByCount "5" @default.
- W2080996925 countsByYear W20809969252016 @default.
- W2080996925 countsByYear W20809969252018 @default.
- W2080996925 countsByYear W20809969252019 @default.
- W2080996925 crossrefType "journal-article" @default.
- W2080996925 hasAuthorship W2080996925A5032537823 @default.
- W2080996925 hasAuthorship W2080996925A5044456642 @default.
- W2080996925 hasAuthorship W2080996925A5047690493 @default.
- W2080996925 hasConcept C12554922 @default.
- W2080996925 hasConcept C147944092 @default.
- W2080996925 hasConcept C170493617 @default.
- W2080996925 hasConcept C181911157 @default.
- W2080996925 hasConcept C185592680 @default.
- W2080996925 hasConcept C194544171 @default.
- W2080996925 hasConcept C2781123555 @default.
- W2080996925 hasConcept C4141045 @default.
- W2080996925 hasConcept C41625074 @default.
- W2080996925 hasConcept C55493867 @default.
- W2080996925 hasConcept C79879829 @default.
- W2080996925 hasConcept C86803240 @default.
- W2080996925 hasConceptScore W2080996925C12554922 @default.
- W2080996925 hasConceptScore W2080996925C147944092 @default.
- W2080996925 hasConceptScore W2080996925C170493617 @default.
- W2080996925 hasConceptScore W2080996925C181911157 @default.
- W2080996925 hasConceptScore W2080996925C185592680 @default.
- W2080996925 hasConceptScore W2080996925C194544171 @default.
- W2080996925 hasConceptScore W2080996925C2781123555 @default.
- W2080996925 hasConceptScore W2080996925C4141045 @default.
- W2080996925 hasConceptScore W2080996925C41625074 @default.
- W2080996925 hasConceptScore W2080996925C55493867 @default.
- W2080996925 hasConceptScore W2080996925C79879829 @default.
- W2080996925 hasConceptScore W2080996925C86803240 @default.
- W2080996925 hasLocation W20809969251 @default.
- W2080996925 hasLocation W20809969252 @default.
- W2080996925 hasOpenAccess W2080996925 @default.
- W2080996925 hasPrimaryLocation W20809969251 @default.
- W2080996925 hasRelatedWork W111279135 @default.
- W2080996925 hasRelatedWork W2005150634 @default.
- W2080996925 hasRelatedWork W2015979114 @default.
- W2080996925 hasRelatedWork W2024867507 @default.
- W2080996925 hasRelatedWork W2032623633 @default.
- W2080996925 hasRelatedWork W2054121895 @default.
- W2080996925 hasRelatedWork W2069392112 @default.
- W2080996925 hasRelatedWork W2070090930 @default.
- W2080996925 hasRelatedWork W3151887034 @default.
- W2080996925 hasRelatedWork W4220954832 @default.
- W2080996925 isParatext "false" @default.
- W2080996925 isRetracted "false" @default.
- W2080996925 magId "2080996925" @default.
- W2080996925 workType "article" @default.