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- W2080996938 abstract "Endotoxin was injected intravenously into rats 48 hours after 70% he-patectomy. The remaining hepatic tissue demonstrated marked hemorrhagic necrosis in high frequency. However, hepatic lesions were slight in other groups such as the group in which heparin was administered simultaneously with injection of endotoxin 48 hours after 70% hepatectomy and the group in which endotoxin was injected 10 days after 70% hepatectomy. Difining of this marked necrosis to be a univisceral Shwartzman reaction in the liver may be justified from (i) conformity of experimental manipulations to those employed in the Shwartzman reaction, (ii) macroscoplcal as well as histological evidence, (iii) formation of microthrombl in hepatic lesions, (iv) inhibition of occurrence of the reaction by heparin, and (v) absence of any remarkable change in other organs. We concluded that the hepatic regenerative state might correspond theoretically to a state of preparedness for the Shwartzman reaction." @default.
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- W2080996938 date "1987-06-01" @default.
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- W2080996938 title "A STUDY ON THE MECHANISM OF ACUTE HEPATIC NECROSIS FOLLOWING PARTIAL RESECTION OF THE LIVER" @default.
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- W2080996938 doi "https://doi.org/10.1111/j.1440-1827.1987.tb00429.x" @default.
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