Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080997656> ?p ?o ?g. }
- W2080997656 endingPage "106" @default.
- W2080997656 startingPage "97" @default.
- W2080997656 abstract "1. The effects of the glycine/NMDA receptor partial agonists, D-cycloserine and (+)-HA-966 and the full agonist, D-serine, on focal seizure threshold and behaviour have been determined in amygdala-kindled rats, i.e. a model of focal (partial) epilepsy. The uncompetitive NMDA receptor antagonist, MK-801, was used for comparison. 2. The high efficacy glycine partial agonist, D-cycloserine, did not alter the threshold for induction of amygdaloid afterdischarges (ADT) at doses of 20-80 mg kg-1 i.p., but significant ADT increases were determined after application of higher doses (160 and 320 mg kg-1). The ADT increases after these high doses were long-lasting; significant elevations were still observed 2 days after drug injection. Determination of D-cycloserine in plasma and brain tissue showed that it was rapidly eliminated from plasma. Compared to peak levels in plasma, only relatively low concentrations of D-cycloserine were measured in brain tissue. 3. The low efficacy glycine partial agonist, (+)-HA-966, 10-40 mg kg-1 i.p., did not alter the ADT or seizure recordings (seizure severity, seizure duration, afterdischarge duration) at ADT currents. However, the drug dose-dependently increased the duration of postictal behavioural and electroencephalographic depression in kindled rats. At the higher dose tested, postictal immobilization was dramatically increased from 3 min to about 120 min. This might indicate that glutamatergic activity is decreased postictally, which is potentiated or prolonged by (+)-HA-966. 4. Like D-cycloserine, the glycine receptor full agonist, D-serine, injected bilaterally into the lateral ventricles at a dose of 5 mumol, significantly increased the ADT, while no effect was seen at a lower dose (2.5 mumol). 5. The anticonvulsant effects observed with D-cycloserine were completely antagonized by combined treatment with (+)-HA-966, indicating that the effects of D-cycloserine were mediated by the glycine/NMDA receptor complex. 6. MK-801, 0.1 mg kg-1, did not alter the focal seizure threshold or seizure recordings at ADT current, but induced marked phencyclidine(PCP)-like behavioural alterations, such as hyperlocomotion, stereotypies and motor impairment. No PCP-like behaviours were observed after D-cycloserine, D-serine or (+)-HA-966. High doses of (+)-HA-966 induced moderate motor impairment in kindled rats. 7. The long lasting increases in seizure threshold observed after the high efficacy glycine partial agonist,D-cycloserine but not the low efficacy partial agonist, (+)-HA-966, may suggest that the effects of D-cycloserine are mediated by adaptive changes in the NMDA receptor complex in response to glycine receptor stimulation.8. Pharmacological intervention at the strychnine-insensitive glycine receptor by high-efficacy partial agonists with systemic bioavailability may be an effective means of increasing seizure-threshold without concomitantly inducing PCP-like adverse effects." @default.
- W2080997656 created "2016-06-24" @default.
- W2080997656 creator A5007732554 @default.
- W2080997656 creator A5010235451 @default.
- W2080997656 creator A5036187783 @default.
- W2080997656 creator A5055852211 @default.
- W2080997656 creator A5086132034 @default.
- W2080997656 date "1994-05-01" @default.
- W2080997656 modified "2023-09-25" @default.
- W2080997656 title "Anticonvulsant effects of the glycine/NMDA receptor ligands d-cycloserine and d-serine but not R-(+)-HA-966 in amygdala-kindled rats" @default.
- W2080997656 cites W123136211 @default.
- W2080997656 cites W1566182596 @default.
- W2080997656 cites W164724745 @default.
- W2080997656 cites W168867634 @default.
- W2080997656 cites W1799745768 @default.
- W2080997656 cites W1925182157 @default.
- W2080997656 cites W1963638552 @default.
- W2080997656 cites W1964384477 @default.
- W2080997656 cites W1969217550 @default.
- W2080997656 cites W1971638658 @default.
- W2080997656 cites W1972331299 @default.
- W2080997656 cites W1975911537 @default.
- W2080997656 cites W1978111369 @default.
- W2080997656 cites W1982619068 @default.
- W2080997656 cites W1982841572 @default.
- W2080997656 cites W1983121532 @default.
- W2080997656 cites W1983971730 @default.
- W2080997656 cites W1984202379 @default.
- W2080997656 cites W1985881706 @default.
- W2080997656 cites W1986641437 @default.
- W2080997656 cites W1989064578 @default.
- W2080997656 cites W1996340934 @default.
- W2080997656 cites W1997677028 @default.
- W2080997656 cites W2008329481 @default.
- W2080997656 cites W2012462745 @default.
- W2080997656 cites W2018021139 @default.
- W2080997656 cites W2024173492 @default.
- W2080997656 cites W2024850658 @default.
- W2080997656 cites W2024969311 @default.
- W2080997656 cites W2026143154 @default.
- W2080997656 cites W2036364614 @default.
- W2080997656 cites W2041491220 @default.
- W2080997656 cites W2051303863 @default.
- W2080997656 cites W2052795247 @default.
- W2080997656 cites W2053215395 @default.
- W2080997656 cites W2053488878 @default.
- W2080997656 cites W2069839495 @default.
- W2080997656 cites W2071881749 @default.
- W2080997656 cites W2080181876 @default.
- W2080997656 cites W2081678712 @default.
- W2080997656 cites W2082488891 @default.
- W2080997656 cites W2082765500 @default.
- W2080997656 cites W2090624084 @default.
- W2080997656 cites W2093980954 @default.
- W2080997656 cites W2097635332 @default.
- W2080997656 cites W2101738963 @default.
- W2080997656 cites W2131279396 @default.
- W2080997656 cites W2199996684 @default.
- W2080997656 cites W2245432458 @default.
- W2080997656 cites W2412834205 @default.
- W2080997656 cites W2417122801 @default.
- W2080997656 cites W2436999317 @default.
- W2080997656 cites W299646246 @default.
- W2080997656 cites W2034400446 @default.
- W2080997656 cites W2474814080 @default.
- W2080997656 doi "https://doi.org/10.1111/j.1476-5381.1994.tb13036.x" @default.
- W2080997656 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1910310" @default.
- W2080997656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8032669" @default.
- W2080997656 hasPublicationYear "1994" @default.
- W2080997656 type Work @default.
- W2080997656 sameAs 2080997656 @default.
- W2080997656 citedByCount "65" @default.
- W2080997656 countsByYear W20809976562013 @default.
- W2080997656 countsByYear W20809976562014 @default.
- W2080997656 countsByYear W20809976562015 @default.
- W2080997656 countsByYear W20809976562016 @default.
- W2080997656 countsByYear W20809976562020 @default.
- W2080997656 countsByYear W20809976562022 @default.
- W2080997656 countsByYear W20809976562023 @default.
- W2080997656 crossrefType "journal-article" @default.
- W2080997656 hasAuthorship W2080997656A5007732554 @default.
- W2080997656 hasAuthorship W2080997656A5010235451 @default.
- W2080997656 hasAuthorship W2080997656A5036187783 @default.
- W2080997656 hasAuthorship W2080997656A5055852211 @default.
- W2080997656 hasAuthorship W2080997656A5086132034 @default.
- W2080997656 hasBestOaLocation W20809976562 @default.
- W2080997656 hasConcept C126322002 @default.
- W2080997656 hasConcept C134018914 @default.
- W2080997656 hasConcept C15744967 @default.
- W2080997656 hasConcept C169760540 @default.
- W2080997656 hasConcept C170493617 @default.
- W2080997656 hasConcept C185592680 @default.
- W2080997656 hasConcept C2775858608 @default.
- W2080997656 hasConcept C2777756961 @default.
- W2080997656 hasConcept C2778186239 @default.
- W2080997656 hasConcept C2778460930 @default.
- W2080997656 hasConcept C2778938600 @default.
- W2080997656 hasConcept C2781122200 @default.