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- W2080998405 abstract "<b><i>Objective:</i></b> To investigate the efficacy and safety of ustekinumab in clinical practice and the influence of several variables on response rates as well as on drug survival. <b><i>Methods:</i></b> Retrospectively collected efficacy and safety data of a cohort of 67 consecutive patients treated with ustekinumab for moderate to severe psoriasis for at least 28 weeks and a maximum of 3 years. Drug survival was analyzed by the Kaplan-Meier method with log-rank test. <b><i>Results:</i></b> PASI75 response rates were numerically higher in patients treated with 45 mg and patients naïve to tumor necrosis factor (TNF)-blocking agents, at all time points. Drug survival was not significantly affected by any variable. <b><i>Conclusion:</i></b> Male sex, weight >100 kg, obesity, and previous failure of one or more TNF inhibitors were associated with a diminished response to treatment. Obesity or previous exposure to anti-TNF agents was not associated with a diminished drug survival in this Spanish cohort." @default.
- W2080998405 created "2016-06-24" @default.
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- W2080998405 date "2015-01-01" @default.
- W2080998405 modified "2023-10-02" @default.
- W2080998405 title "Long-Term Efficacy, Safety and Drug Survival of Ustekinumab in a Spanish Cohort of Patients with Moderate to Severe Plaque Psoriasis" @default.
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- W2080998405 doi "https://doi.org/10.1159/000366499" @default.
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