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- W2081003057 abstract "Arzanol is a novel phloroglucinol α -pyrone, isolated from a Mediterranean plant Helichrysum italicum (Roth) Don ssp. microphyllum which belongs to the family Asteraceae. Arzanol has been reported to possess a variety of pharmacological activities. However, anti-inflammatory, anti-HIV, and antioxidant activities have been studied in some detail. Arzanol has been reported to inhibit inflammatory transcription factor NF κ B activation, HIV replication in T cells, releases of IL-1 β , IL-6, IL-8, and TNF- α , and biosynthesis of PGE 2 by potentially inhibiting mPGES-1 enzyme. Diversity of mechanisms of actions of arzanol may be useful in treatment of disease involving these inflammatory mediators such as autoimmune diseases and cancer. This review presents comprehensive information on the chemistry, structure-activity relationship, and pharmacological activities of arzanol. In addition this review discusses recent developments and the scope for future research in these aspects." @default.
- W2081003057 created "2016-06-24" @default.
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- W2081003057 date "2013-01-01" @default.
- W2081003057 modified "2023-10-04" @default.
- W2081003057 title "Arzanol, a Potent mPGES-1 Inhibitor: Novel Anti-Inflammatory Agent" @default.
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- W2081003057 doi "https://doi.org/10.1155/2013/986429" @default.
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