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- W2081003301 abstract "The diffusional permeability of the isolated rabbit ciliary epithelium to a variety of hydrophilic solutes has been measured under normal and prostaglandin-stimulated conditions. In both normal and prostaglandin-treated tissue there is a strong relationship of permeability to both molecular radius and molecular weight. A thermodynamic analysis of the data, together with values of relfection coefficient and hydraulic conductivity, leads to the conclusion that there are large interactions between solute and solvent in the membrane. The flow of solute is, therefore, highly dependent upon a hydrostatic pressure-induced water flow across the membrane. The prostaglandin E2-treated tissue shows an elevated hydraulic conductivity, together with an increased diffusional permeability to two different molecular sizes of dextran tested. The permeability to urea and sucrose is, however, relatively unaffected. Since prostaglandin affected the permeability only of the higher molecular weight compounds, it would appear that the normal pore size of the ciliary epithelium is about 10 Å. Determination of the effect of hydrostatic pressure on the fluxes of sodium and chloride reveal that the fluid emerging across the isolated ciliary epithelium is slightly hypertonic with respect to aqueous. In addition, the fluxes appear to be directly related to the net fluid flow indicating the strong effect of solvent flow on solute movement. Active transport appears to be affected by ultrafiltration." @default.
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- W2081003301 title "Solute permeability of the normal and prostaglandin-stimulated ciliary epithelium and the effect of ultrafiltration on active transport" @default.
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- W2081003301 doi "https://doi.org/10.1016/0014-4835(75)90039-1" @default.
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