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• W2081004046 endingPage "601" @default.
• W2081004046 startingPage "583" @default.
• W2081004046 abstract "The simian lentivirus strain SIVsmmFGb is a viral swarm population inducing neuropathology in over 90% of infected pigtailed macaques and serves as a reliable model for HIV neuropathogenesis. However, little is understood about the genetic diversity of this virus, how said diversity influences the initial seeding of the central nervous system and lymph nodes, or whether the virus forms distinct genetic compartments between tissues during acute infection. In this study, we establish that our SIVsmmFGb stock virus contains four genetically distinct envelope V1 region groups, three distinct integrase groups, and two Nef groups. We demonstrate that initial central nervous system and lymph node seeding reduces envelope V1 and integrase genetic diversity but has a variable effect on Nef diversity. SIVsmmFGb envelope V1 region genes from the basal ganglia, cerebellum, and hippocampus form distinct genetic compartments from each other, the midfrontal cortex, and the lymph nodes. Basal ganglia, cerebellum, hippocampus, and midfrontal cortex-derived nef genes all form distinct genetic compartments from each other, as well as from the lymph nodes. We also find basal ganglia, hippocampus, and midfrontal cortex-derived integrase sequences forming distinct compartments from both of the lymph nodes and that the hippocampus and midfrontal cortex form separate compartments from the cerebellum, while the axillary and mesenteric lymph nodes compartmentalize separately from each other. Compartmentalization of the envelope V1 genes resulted from positive selection, and compartmentalization of the nef and integrase genes from negative selection. These results indicate restrictions on virus genetic diversity during initial tissue seeding in neuropathogenic SIV infection." @default.
• W2081004046 created "2016-06-24" @default.
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• W2081004046 creator A5065555246 @default.
• W2081004046 creator A5083993328 @default.
• W2081004046 creator A5087925525 @default.
• W2081004046 date "2009-06-01" @default.
• W2081004046 modified "2023-09-27" @default.
• W2081004046 title "Reduced Genetic Diversity in Lymphoid and Central Nervous System Tissues and Selection-Induced Tissue-Specific Compartmentalization of Neuropathogenic SIVsmmFGb during Acute Infection" @default.
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• W2081004046 doi "https://doi.org/10.1089/aid.2008.0240" @default.
• W2081004046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2853841" @default.
• W2081004046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19500015" @default.
• W2081004046 hasPublicationYear "2009" @default.
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