Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081009013> ?p ?o ?g. }
- W2081009013 endingPage "1627" @default.
- W2081009013 startingPage "1619" @default.
- W2081009013 abstract "Alterations in metabolic pathways are gaining attention as important environmental factors affecting life span, but the determination of specific metabolic pathways and enzymes involved in life span remains largely unexplored. By applying an NMR-based metabolomics approach to a calorie-restricted yeast (Saccharomyces cerevisiae) model, we found that alanine level is inversely correlated with yeast chronological life span. The involvement of the alanine-metabolizing pathway in the life span was tested using a deletion mutant of ALT1, the gene for a key alanine-metabolizing enzyme. The mutant exhibited increased endogenous alanine level and much shorter life span, demonstrating the importance of ALT1 and alanine metabolic pathways in the life span. ALT1’s effect on life span was independent of the TOR pathway, as revealed by a tor1 deletion mutant. Further mechanistic studies showed that alt1 deletion suppresses cytochrome c oxidase subunit 2 expression, ultimately generating reactive oxygen species. Overall, ALT1 seems critical in determining yeast life span, and our approach should be useful for the mechanistic studies of life span determinations." @default.
- W2081009013 created "2016-06-24" @default.
- W2081009013 creator A5003261759 @default.
- W2081009013 creator A5005719054 @default.
- W2081009013 creator A5007846757 @default.
- W2081009013 creator A5015626811 @default.
- W2081009013 creator A5025787222 @default.
- W2081009013 creator A5028979905 @default.
- W2081009013 creator A5044249851 @default.
- W2081009013 creator A5046990396 @default.
- W2081009013 creator A5051862342 @default.
- W2081009013 creator A5090535135 @default.
- W2081009013 creator A5030955805 @default.
- W2081009013 date "2013-03-25" @default.
- W2081009013 modified "2023-10-14" @default.
- W2081009013 title "Alanine-Metabolizing Enzyme Alt1 Is Critical in Determining Yeast Life Span, As Revealed by Combined Metabolomic and Genetic Studies" @default.
- W2081009013 cites W1521681869 @default.
- W2081009013 cites W1598035363 @default.
- W2081009013 cites W1656781980 @default.
- W2081009013 cites W1951314249 @default.
- W2081009013 cites W1966687534 @default.
- W2081009013 cites W1971498805 @default.
- W2081009013 cites W1974032935 @default.
- W2081009013 cites W1980969730 @default.
- W2081009013 cites W1982647833 @default.
- W2081009013 cites W1986039855 @default.
- W2081009013 cites W1996181447 @default.
- W2081009013 cites W2002088854 @default.
- W2081009013 cites W2007607879 @default.
- W2081009013 cites W2007800549 @default.
- W2081009013 cites W2009332336 @default.
- W2081009013 cites W2010520132 @default.
- W2081009013 cites W2013894349 @default.
- W2081009013 cites W2017519940 @default.
- W2081009013 cites W2024260597 @default.
- W2081009013 cites W2032351956 @default.
- W2081009013 cites W2048376025 @default.
- W2081009013 cites W2053493267 @default.
- W2081009013 cites W2054059225 @default.
- W2081009013 cites W2056673369 @default.
- W2081009013 cites W2058642498 @default.
- W2081009013 cites W2063013559 @default.
- W2081009013 cites W2065197926 @default.
- W2081009013 cites W2065440747 @default.
- W2081009013 cites W2066678388 @default.
- W2081009013 cites W2073414410 @default.
- W2081009013 cites W2080094749 @default.
- W2081009013 cites W2083340629 @default.
- W2081009013 cites W2084054222 @default.
- W2081009013 cites W2084708023 @default.
- W2081009013 cites W2088381487 @default.
- W2081009013 cites W2102646072 @default.
- W2081009013 cites W2110777399 @default.
- W2081009013 cites W2111262978 @default.
- W2081009013 cites W2120714068 @default.
- W2081009013 cites W2121367656 @default.
- W2081009013 cites W2121945497 @default.
- W2081009013 cites W2122073743 @default.
- W2081009013 cites W2128329787 @default.
- W2081009013 cites W2130382164 @default.
- W2081009013 cites W2134485351 @default.
- W2081009013 cites W2138138136 @default.
- W2081009013 cites W2143996615 @default.
- W2081009013 cites W2158320951 @default.
- W2081009013 cites W2160751669 @default.
- W2081009013 cites W2164498083 @default.
- W2081009013 cites W2165319081 @default.
- W2081009013 cites W2166613333 @default.
- W2081009013 doi "https://doi.org/10.1021/pr300979r" @default.
- W2081009013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23527786" @default.
- W2081009013 hasPublicationYear "2013" @default.
- W2081009013 type Work @default.
- W2081009013 sameAs 2081009013 @default.
- W2081009013 citedByCount "20" @default.
- W2081009013 countsByYear W20810090132014 @default.
- W2081009013 countsByYear W20810090132015 @default.
- W2081009013 countsByYear W20810090132016 @default.
- W2081009013 countsByYear W20810090132017 @default.
- W2081009013 countsByYear W20810090132018 @default.
- W2081009013 countsByYear W20810090132019 @default.
- W2081009013 countsByYear W20810090132021 @default.
- W2081009013 countsByYear W20810090132022 @default.
- W2081009013 countsByYear W20810090132023 @default.
- W2081009013 crossrefType "journal-article" @default.
- W2081009013 hasAuthorship W2081009013A5003261759 @default.
- W2081009013 hasAuthorship W2081009013A5005719054 @default.
- W2081009013 hasAuthorship W2081009013A5007846757 @default.
- W2081009013 hasAuthorship W2081009013A5015626811 @default.
- W2081009013 hasAuthorship W2081009013A5025787222 @default.
- W2081009013 hasAuthorship W2081009013A5028979905 @default.
- W2081009013 hasAuthorship W2081009013A5030955805 @default.
- W2081009013 hasAuthorship W2081009013A5044249851 @default.
- W2081009013 hasAuthorship W2081009013A5046990396 @default.
- W2081009013 hasAuthorship W2081009013A5051862342 @default.
- W2081009013 hasAuthorship W2081009013A5090535135 @default.
- W2081009013 hasConcept C104317684 @default.
- W2081009013 hasConcept C143065580 @default.
- W2081009013 hasConcept C181199279 @default.