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- W2081016768 abstract "We report the SAR studies of 43 ionone-based chalcones that demonstrate substantial in vitro anti-proliferative activities in LNCaP, MDA-PCa-2b, 22Rv1, C4-2B and PC-3 prostate cancer cell lines. Compound 25 with an IC(50) value of 0.74 microM in LNCaP cells potently antagonizes DHT-induced transactivation of the wild type and the clinically relevant T877A, W741C and H874Y mutated androgen receptors, representing a novel chalcone as pan-antagonist of androgen receptor." @default.
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- W2081016768 date "2009-02-01" @default.
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- W2081016768 title "Syntheses and potential anti-prostate cancer activities of ionone-based chalcones" @default.
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- W2081016768 doi "https://doi.org/10.1016/j.bmcl.2008.12.089" @default.
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