Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081021567> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2081021567 endingPage "711" @default.
- W2081021567 startingPage "693" @default.
- W2081021567 abstract "1. Solutions of ethylhydrocupreine (optochin) hydrochloride show a pronounced bactericidal activity for pneumococci in pleural pus. 2. The highest tolerated dose of ethylhydrocupreine hydrochloride for guinea pigs by intrapleural injection is about 0.2 to 0.3 cc. of a 1:100 solution per 100 gm. of weight, corresponding to 2 to 3 cc. of solution or 0.02 to 0.03 gm. of the drug per kilo of weight. 3. The injection of 1 cc. of a 1:500 solution of ethylhydrocupreine hydrochloride into each pleural cavity of a guinea pig weighing from 350 to 500 gm. produces no evidences of toxicity or irritation of the pleura. 4. The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis, which generally terminates fatally within 72 hours with pneumococcus bacteremia. 5. The injection of 1 cc. of 1:500 solutions of ethlylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results were observed with dogs. 6. The intrapleural injection of mixtures of ethylhydrocupreine, sodium oleate, and boric acid (Lamar) has also shown a decided curative effect in acute suppurative pneumococcus pleuritis of guinea pigs. 7. These and similar experiments on pneumococcus meningitis suggest that in chemotherapeutic investigations certain drugs may be injected into serous cavities in amounts exerting distinct bactericidal activity in vivo without producing local irritation or general toxic effects." @default.
- W2081021567 created "2016-06-24" @default.
- W2081021567 creator A5019363633 @default.
- W2081021567 creator A5027030710 @default.
- W2081021567 date "1921-06-01" @default.
- W2081021567 modified "2023-09-27" @default.
- W2081021567 title "CHEMOTHERAPEUTIC STUDIES WITH ETHYLHYDROCUPREINE HYDROCHLORIDE IN EXPERIMENTAL PNEUMOCOCCUS PLEURITIS" @default.
- W2081021567 cites W1999505252 @default.
- W2081021567 cites W2036745253 @default.
- W2081021567 doi "https://doi.org/10.1084/jem.33.6.693" @default.
- W2081021567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2128296" @default.
- W2081021567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19868530" @default.
- W2081021567 hasPublicationYear "1921" @default.
- W2081021567 type Work @default.
- W2081021567 sameAs 2081021567 @default.
- W2081021567 citedByCount "4" @default.
- W2081021567 crossrefType "journal-article" @default.
- W2081021567 hasAuthorship W2081021567A5019363633 @default.
- W2081021567 hasAuthorship W2081021567A5027030710 @default.
- W2081021567 hasBestOaLocation W20810215671 @default.
- W2081021567 hasConcept C126322002 @default.
- W2081021567 hasConcept C141071460 @default.
- W2081021567 hasConcept C178790620 @default.
- W2081021567 hasConcept C185592680 @default.
- W2081021567 hasConcept C2776460385 @default.
- W2081021567 hasConcept C2778815084 @default.
- W2081021567 hasConcept C2778978224 @default.
- W2081021567 hasConcept C2779127879 @default.
- W2081021567 hasConcept C2779634585 @default.
- W2081021567 hasConcept C2781253189 @default.
- W2081021567 hasConcept C501593827 @default.
- W2081021567 hasConcept C71924100 @default.
- W2081021567 hasConcept C86803240 @default.
- W2081021567 hasConcept C89423630 @default.
- W2081021567 hasConcept C98274493 @default.
- W2081021567 hasConceptScore W2081021567C126322002 @default.
- W2081021567 hasConceptScore W2081021567C141071460 @default.
- W2081021567 hasConceptScore W2081021567C178790620 @default.
- W2081021567 hasConceptScore W2081021567C185592680 @default.
- W2081021567 hasConceptScore W2081021567C2776460385 @default.
- W2081021567 hasConceptScore W2081021567C2778815084 @default.
- W2081021567 hasConceptScore W2081021567C2778978224 @default.
- W2081021567 hasConceptScore W2081021567C2779127879 @default.
- W2081021567 hasConceptScore W2081021567C2779634585 @default.
- W2081021567 hasConceptScore W2081021567C2781253189 @default.
- W2081021567 hasConceptScore W2081021567C501593827 @default.
- W2081021567 hasConceptScore W2081021567C71924100 @default.
- W2081021567 hasConceptScore W2081021567C86803240 @default.
- W2081021567 hasConceptScore W2081021567C89423630 @default.
- W2081021567 hasConceptScore W2081021567C98274493 @default.
- W2081021567 hasIssue "6" @default.
- W2081021567 hasLocation W20810215671 @default.
- W2081021567 hasLocation W20810215672 @default.
- W2081021567 hasLocation W20810215673 @default.
- W2081021567 hasLocation W20810215674 @default.
- W2081021567 hasOpenAccess W2081021567 @default.
- W2081021567 hasPrimaryLocation W20810215671 @default.
- W2081021567 hasRelatedWork W1752492892 @default.
- W2081021567 hasRelatedWork W1921744819 @default.
- W2081021567 hasRelatedWork W1976429328 @default.
- W2081021567 hasRelatedWork W2089098101 @default.
- W2081021567 hasRelatedWork W2310839381 @default.
- W2081021567 hasRelatedWork W2353798875 @default.
- W2081021567 hasRelatedWork W2369744902 @default.
- W2081021567 hasRelatedWork W2375725826 @default.
- W2081021567 hasRelatedWork W2397734907 @default.
- W2081021567 hasRelatedWork W2426767877 @default.
- W2081021567 hasVolume "33" @default.
- W2081021567 isParatext "false" @default.
- W2081021567 isRetracted "false" @default.
- W2081021567 magId "2081021567" @default.
- W2081021567 workType "article" @default.