FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081038081> ?p ?o ?g. }

• W2081038081 endingPage "10266" @default.
• W2081038081 startingPage "10259" @default.
• W2081038081 abstract "Replication factor C3 (RFC3) is an oncogene that can potentially predict prognosis in a variety of human cancers. RFC3 expression in ovarian carcinoma has not yet been determined. In this study, we evaluated the messenger RNA (mRNA) and protein expression levels of RFC3 in normal ovarian and ovarian carcinoma tissues using reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry, and Western blots (WB). Results showed that higher RFC3 mRNA and protein levels were detected in ovarian carcinoma tissues by RT-PCR and WB. High RFC3 expression was defined as positive staining in >70 % of each tumor cell. High RFC3 expression was detected in 28.1, 17.6, 11.1, and 5.0 % of invasive carcinomas, borderline tumors, cystadenomas, and in normal ovary cells, respectively. Overexpression of RFC3 was associated with later pN status (p = 0.001), pM status (p = 0.001), and advanced International Federation of Gynecology and Obstetrics (FIGO) stage (p = 0.012) in ovarian carcinomas. Univariate survival analyses showed that RFC3 overexpression was also associated with shortened patient survival (mean 7.7 months in tumors with RFC3 overexpression vs 92.9 months in tumors with normal RFC3 levels; p < 0.001). In multivariate analyses, RFC3 protein levels were a significant prognostic factor for ovarian carcinoma (p < 0.001). In conclusion, our findings suggest that RFC3 protein is an important and independent biomarker with prognostic implications for patients with ovarian carcinoma." @default.
• W2081038081 created "2016-06-24" @default.
• W2081038081 creator A5002146452 @default.
• W2081038081 creator A5005839192 @default.
• W2081038081 creator A5014883258 @default.
• W2081038081 creator A5056606673 @default.
• W2081038081 creator A5065143293 @default.
• W2081038081 creator A5067722877 @default.
• W2081038081 creator A5087827843 @default.
• W2081038081 date "2014-07-17" @default.
• W2081038081 modified "2023-10-18" @default.
• W2081038081 title "Overexpression of RFC3 is correlated with ovarian tumor development and poor prognosis" @default.
• W2081038081 cites W1916339093 @default.
• W2081038081 cites W1944079546 @default.
• W2081038081 cites W1992686564 @default.
• W2081038081 cites W1998258610 @default.
• W2081038081 cites W2002025964 @default.
• W2081038081 cites W2018333015 @default.
• W2081038081 cites W2018535900 @default.
• W2081038081 cites W2021421164 @default.
• W2081038081 cites W2023985769 @default.
• W2081038081 cites W2034260252 @default.
• W2081038081 cites W2039174864 @default.
• W2081038081 cites W2041258641 @default.
• W2081038081 cites W2060035371 @default.
• W2081038081 cites W2063979868 @default.
• W2081038081 cites W2070369494 @default.
• W2081038081 cites W2075711878 @default.
• W2081038081 cites W2078194375 @default.
• W2081038081 cites W2081772067 @default.
• W2081038081 cites W2088925159 @default.
• W2081038081 cites W2090968329 @default.
• W2081038081 cites W2094785950 @default.
• W2081038081 cites W2104337990 @default.
• W2081038081 cites W2107031745 @default.
• W2081038081 cites W2108630902 @default.
• W2081038081 cites W2118656195 @default.
• W2081038081 cites W2119621725 @default.
• W2081038081 cites W2124890939 @default.
• W2081038081 cites W2126196172 @default.
• W2081038081 cites W2127886165 @default.
• W2081038081 cites W2130648158 @default.
• W2081038081 cites W2166738705 @default.
• W2081038081 doi "https://doi.org/10.1007/s13277-014-2216-2" @default.
• W2081038081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25030735" @default.
• W2081038081 hasPublicationYear "2014" @default.
• W2081038081 type Work @default.
• W2081038081 sameAs 2081038081 @default.
• W2081038081 citedByCount "13" @default.
• W2081038081 countsByYear W20810380812015 @default.
• W2081038081 countsByYear W20810380812017 @default.
• W2081038081 countsByYear W20810380812018 @default.
• W2081038081 countsByYear W20810380812019 @default.
• W2081038081 countsByYear W20810380812022 @default.
• W2081038081 countsByYear W20810380812023 @default.
• W2081038081 crossrefType "journal-article" @default.
• W2081038081 hasAuthorship W2081038081A5002146452 @default.
• W2081038081 hasAuthorship W2081038081A5005839192 @default.
• W2081038081 hasAuthorship W2081038081A5014883258 @default.
• W2081038081 hasAuthorship W2081038081A5056606673 @default.
• W2081038081 hasAuthorship W2081038081A5065143293 @default.
• W2081038081 hasAuthorship W2081038081A5067722877 @default.
• W2081038081 hasAuthorship W2081038081A5087827843 @default.
• W2081038081 hasConcept C104317684 @default.
• W2081038081 hasConcept C105580179 @default.
• W2081038081 hasConcept C121608353 @default.
• W2081038081 hasConcept C126322002 @default.
• W2081038081 hasConcept C142724271 @default.
• W2081038081 hasConcept C143998085 @default.
• W2081038081 hasConcept C144301174 @default.
• W2081038081 hasConcept C204232928 @default.
• W2081038081 hasConcept C2777546739 @default.
• W2081038081 hasConcept C2778324911 @default.
• W2081038081 hasConcept C2780427987 @default.
• W2081038081 hasConcept C2781018059 @default.
• W2081038081 hasConcept C2781197716 @default.
• W2081038081 hasConcept C29537977 @default.
• W2081038081 hasConcept C3019054536 @default.
• W2081038081 hasConcept C38180746 @default.
• W2081038081 hasConcept C502942594 @default.
• W2081038081 hasConcept C55493867 @default.
• W2081038081 hasConcept C71924100 @default.
• W2081038081 hasConcept C86803240 @default.
• W2081038081 hasConceptScore W2081038081C104317684 @default.
• W2081038081 hasConceptScore W2081038081C105580179 @default.
• W2081038081 hasConceptScore W2081038081C121608353 @default.
• W2081038081 hasConceptScore W2081038081C126322002 @default.
• W2081038081 hasConceptScore W2081038081C142724271 @default.
• W2081038081 hasConceptScore W2081038081C143998085 @default.
• W2081038081 hasConceptScore W2081038081C144301174 @default.
• W2081038081 hasConceptScore W2081038081C204232928 @default.
• W2081038081 hasConceptScore W2081038081C2777546739 @default.
• W2081038081 hasConceptScore W2081038081C2778324911 @default.
• W2081038081 hasConceptScore W2081038081C2780427987 @default.
• W2081038081 hasConceptScore W2081038081C2781018059 @default.
• W2081038081 hasConceptScore W2081038081C2781197716 @default.
• W2081038081 hasConceptScore W2081038081C29537977 @default.
• W2081038081 hasConceptScore W2081038081C3019054536 @default.

• next