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• W2081038501 abstract "Abstract Immunizations via the i.n. and intravaginal (ivag) routes effectively generate strong genital tract antibody‐mediated immunity. To what extent the same is true for T‐cell responses is incompletely known. Therefore, we set out to investigate optimal conditions for stimulation of genital tract CD4 + T‐cell responses, using adoptive transfer of mouse DO11.10 TCR transgenic T cells specific for OVA and OVA conjugated to cholera toxin (CT) as an immunogen. We observed that progesterone was required for a T‐cell response following ivag immunization, whereas estradiol prevented a response. Although i.n. immunization stimulated OVA‐specific CD4 + T‐cell responses in the draining LNs, it was substantially less effective compared to ivag. More importantly, an ivag booster immunization was absolutely required to attract T cells to the genital tract mucosa itself. While clinical use of CT is precluded because of its toxicity, we developed a combined adjuvant vector based on a non‐toxic derivative of CT and immune‐stimulating complexes. The CTA1‐DD/immune‐stimulating complexes (ISCOMs) adjuvant together with major outer membrane protein was effective at stimulating genital tract CD4 + T‐cell immunity and protection against a live chlamydial infection, which holds promise for the development of mucosal vaccines against sexually transmitted infections." @default.
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• W2081038501 date "2011-08-26" @default.
• W2081038501 modified "2023-10-18" @default.
• W2081038501 title "CD4+ T-cell immunity in the female genital tract is critically dependent on local mucosal immunization" @default.
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• W2081038501 doi "https://doi.org/10.1002/eji.201041297" @default.
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