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- W2081052012 abstract "This chapter reviews the morphology of the squid giant axon, as revealed mainly by the electron microscope. It correlates the structural details with the functional behavior of the giant fiber. It also examines the most remarkable structural features of this preparation: (1) the large size of the giant axon, over 200 μm in diameter in most species, (2) the apparent polarization of the axoplasm constituents—neurofilaments, microtubules, endoplasmic reticulum, and possibly mitochondria, which appear to be more concentrated toward the periphery, (3) the characteristic Schwann layer, closely apposed to the axon surface and constituting a network of extracellular spaces, (4) the intimate contact, at certain specialized sites, between the axon and its satellite Schwann cell plasma membranes. The chapter also discusses the usefulness of the squid axon as a source for preparing membrane fractions. The latter have been important for biochemical and pharmacological studies in the neurosciences and have led to methods for the isolation and purification of components of excitable membranes such as the sodium channel." @default.
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- W2081052012 date "1964-07-01" @default.
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- W2081052012 title "Extracellular pathways in the peripheral nerve fibres: Schwann-cell-layer permeability to thorium dioxide" @default.
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- W2081052012 doi "https://doi.org/10.1016/0926-6577(64)90177-9" @default.
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