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- W2081057543 abstract "In neonatal vascular smooth muscle (VSM) cells, activation of protein kinase C can block the mitogenic response to alpha-thrombin. The molecular mechanism for this growth inhibition was investigated by looking at early transcriptional events in the cell cycle. Both thrombin and phorbol-12-myristate-13-acetate (PMA) induced mRNA for the c-myc oncogene; peak levels of expression were found 4-5 h after exposure to either agent. When thrombin and PMA were added together, c-myc expression was increased synergistically; down-regulation of protein kinase C suppressed induction of c-myc by thrombin. Thus, c-myc expression varied inversely with cell growth under these conditions. Thrombin and PMA also both induced expression of mRNA for the PDGF-A chain over 4-7h. As for c-myc, PMA and thrombin synergistically increased expression of the PDGF A-chain under conditions where PMA inhibits thrombin-induced DNA synthesis. Thus, mitogenesis and early growth-related gene expression was dissociated during PMA-mediated growth inhibition." @default.
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- W2081057543 date "1991-12-01" @default.
- W2081057543 modified "2023-09-24" @default.
- W2081057543 title "Dissociation between activation of growth-related genes and mitogenic responses of neonatal vascular smooth muscle cells" @default.
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- W2081057543 doi "https://doi.org/10.1016/0006-291x(91)91235-5" @default.
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