FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081060643> ?p ?o ?g. }

• W2081060643 endingPage "667" @default.
• W2081060643 startingPage "661" @default.
• W2081060643 abstract "Ribavirin is found to be absorbed in the intestine through the human concentrative nucleoside transporter 2 (hCNT2). Cellular uptake of ribavirin was strongly inhibited by purine nucleoside in an in vitro study. This study aims to examine the effects of dietary purine on the pharmacokinetics of orally administered ribavirin in vivo. Twenty healthy participants were enrolled in a randomized, 2‐period crossover study. Participants were administered a single 600‐mg oral dose of ribavirin after either a high‐purine meal or a low‐purine meal. Serial blood samples were collected predose and over 144 hours after dosing. Ribavirin concentrations were measured by liquid chromatography/tandem mass spectrometry. In comparison with corresponding plasma values of ribavirin following a high‐purine meal, C max , AUC 0–144 and AUC 0–∞ of ribavirin following a low‐purine meal were 136% (90% confidence internal [CI]: 120%–155%), 134% (90% CI: 118%–153%), and 139% (90% CI: 120%–159%), respectively. This study indicates that dietary purines have an effect on ribavirin absorption. Dosage regimens of ribavirin might need to be adjusted according to the purine content of the meal." @default.
• W2081060643 created "2016-06-24" @default.
• W2081060643 creator A5017128943 @default.
• W2081060643 creator A5047393355 @default.
• W2081060643 creator A5058221865 @default.
• W2081060643 creator A5067855113 @default.
• W2081060643 creator A5080523264 @default.
• W2081060643 creator A5083128420 @default.
• W2081060643 creator A5085144330 @default.
• W2081060643 date "2009-06-01" @default.
• W2081060643 modified "2023-10-18" @default.
• W2081060643 title "Effect of Dietary Purines on the Pharmacokinetics of Orally Administered Ribavirin" @default.
• W2081060643 cites W1990291419 @default.
• W2081060643 cites W2007122128 @default.
• W2081060643 cites W2007209701 @default.
• W2081060643 cites W2009523275 @default.
• W2081060643 cites W2027545702 @default.
• W2081060643 cites W2028952157 @default.
• W2081060643 cites W2040463160 @default.
• W2081060643 cites W2040884268 @default.
• W2081060643 cites W2061147784 @default.
• W2081060643 cites W2095410184 @default.
• W2081060643 cites W2103582664 @default.
• W2081060643 cites W2112876622 @default.
• W2081060643 cites W2127685726 @default.
• W2081060643 cites W225101619 @default.
• W2081060643 cites W2269974365 @default.
• W2081060643 doi "https://doi.org/10.1177/0091270009335002" @default.
• W2081060643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19369574" @default.
• W2081060643 hasPublicationYear "2009" @default.
• W2081060643 type Work @default.
• W2081060643 sameAs 2081060643 @default.
• W2081060643 citedByCount "17" @default.
• W2081060643 countsByYear W20810606432012 @default.
• W2081060643 countsByYear W20810606432013 @default.
• W2081060643 countsByYear W20810606432014 @default.
• W2081060643 countsByYear W20810606432015 @default.
• W2081060643 countsByYear W20810606432016 @default.
• W2081060643 countsByYear W20810606432017 @default.
• W2081060643 countsByYear W20810606432018 @default.
• W2081060643 countsByYear W20810606432020 @default.
• W2081060643 countsByYear W20810606432021 @default.
• W2081060643 countsByYear W20810606432022 @default.
• W2081060643 crossrefType "journal-article" @default.
• W2081060643 hasAuthorship W2081060643A5017128943 @default.
• W2081060643 hasAuthorship W2081060643A5047393355 @default.
• W2081060643 hasAuthorship W2081060643A5058221865 @default.
• W2081060643 hasAuthorship W2081060643A5067855113 @default.
• W2081060643 hasAuthorship W2081060643A5080523264 @default.
• W2081060643 hasAuthorship W2081060643A5083128420 @default.
• W2081060643 hasAuthorship W2081060643A5085144330 @default.
• W2081060643 hasConcept C112705442 @default.
• W2081060643 hasConcept C126322002 @default.
• W2081060643 hasConcept C142724271 @default.
• W2081060643 hasConcept C159047783 @default.
• W2081060643 hasConcept C169586020 @default.
• W2081060643 hasConcept C181199279 @default.
• W2081060643 hasConcept C181389837 @default.
• W2081060643 hasConcept C185592680 @default.
• W2081060643 hasConcept C204787440 @default.
• W2081060643 hasConcept C2522874641 @default.
• W2081060643 hasConcept C27081682 @default.
• W2081060643 hasConcept C2776408679 @default.
• W2081060643 hasConcept C2776476023 @default.
• W2081060643 hasConcept C2777056448 @default.
• W2081060643 hasConcept C2777288759 @default.
• W2081060643 hasConcept C2778345441 @default.
• W2081060643 hasConcept C2780040827 @default.
• W2081060643 hasConcept C55493867 @default.
• W2081060643 hasConcept C71924100 @default.
• W2081060643 hasConcept C87813604 @default.
• W2081060643 hasConcept C98274493 @default.
• W2081060643 hasConceptScore W2081060643C112705442 @default.
• W2081060643 hasConceptScore W2081060643C126322002 @default.
• W2081060643 hasConceptScore W2081060643C142724271 @default.
• W2081060643 hasConceptScore W2081060643C159047783 @default.
• W2081060643 hasConceptScore W2081060643C169586020 @default.
• W2081060643 hasConceptScore W2081060643C181199279 @default.
• W2081060643 hasConceptScore W2081060643C181389837 @default.
• W2081060643 hasConceptScore W2081060643C185592680 @default.
• W2081060643 hasConceptScore W2081060643C204787440 @default.
• W2081060643 hasConceptScore W2081060643C2522874641 @default.
• W2081060643 hasConceptScore W2081060643C27081682 @default.
• W2081060643 hasConceptScore W2081060643C2776408679 @default.
• W2081060643 hasConceptScore W2081060643C2776476023 @default.
• W2081060643 hasConceptScore W2081060643C2777056448 @default.
• W2081060643 hasConceptScore W2081060643C2777288759 @default.
• W2081060643 hasConceptScore W2081060643C2778345441 @default.
• W2081060643 hasConceptScore W2081060643C2780040827 @default.
• W2081060643 hasConceptScore W2081060643C55493867 @default.
• W2081060643 hasConceptScore W2081060643C71924100 @default.
• W2081060643 hasConceptScore W2081060643C87813604 @default.
• W2081060643 hasConceptScore W2081060643C98274493 @default.
• W2081060643 hasIssue "6" @default.
• W2081060643 hasLocation W20810606431 @default.
• W2081060643 hasLocation W20810606432 @default.
• W2081060643 hasOpenAccess W2081060643 @default.
• W2081060643 hasPrimaryLocation W20810606431 @default.

• next