Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081067748> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2081067748 endingPage "321" @default.
- W2081067748 startingPage "317" @default.
- W2081067748 abstract "The calcium channel blocker verapamil has, in addition to its other properties, been shown to be a local anesthetic. Its concurrent use in a patient undergoing regional anesthesia may, therefore, increase the potential risk for local anesthetic toxicity. To evaluate this possibility, the effect of verapamil on the median lethal dose (LD50) of lidocaine and bupivacaine in mice was determined. Immediate pretreatment with verapamil increased the mortality of mice given the LD50 dose of lidocaine to 74%, and in mice given the LD50 doses of bupivacaine, to 82%. In animals pretreated with verapamil and calcium chloride, the mortality associated with the administration of LD50 doses of lidocaine and bupivacaine decreased to 43% and 48%, respectively, thus returning the mortality rate back to the LD50 of the local anesthetics when administered alone, It seems that the combined administration of local anesthetic and verapamil results in a significant drug interaction: the resulting blockade of sodium and calcium channels apparently impairs membrane function to a greater degree than with either drug alone. Additional investigation is warranted, and caution should be exercised in giving verapamil to patients during regional anesthesia. Should an adverse drug interaction ensue, the administration of calcium may be beneficial." @default.
- W2081067748 created "2016-06-24" @default.
- W2081067748 creator A5002022325 @default.
- W2081067748 creator A5019828694 @default.
- W2081067748 creator A5021075276 @default.
- W2081067748 creator A5030687612 @default.
- W2081067748 date "1988-04-01" @default.
- W2081067748 modified "2023-09-26" @default.
- W2081067748 title "Verapamil Increases the Toxicity of Local Anesthetics" @default.
- W2081067748 cites W1971524300 @default.
- W2081067748 cites W1982268861 @default.
- W2081067748 cites W1989537538 @default.
- W2081067748 cites W1996361797 @default.
- W2081067748 cites W2006398255 @default.
- W2081067748 cites W2010830095 @default.
- W2081067748 cites W2010927027 @default.
- W2081067748 cites W2024316967 @default.
- W2081067748 cites W2029087402 @default.
- W2081067748 cites W2036309159 @default.
- W2081067748 cites W2038206330 @default.
- W2081067748 cites W2039162261 @default.
- W2081067748 cites W2079678344 @default.
- W2081067748 cites W2080771434 @default.
- W2081067748 cites W2082671341 @default.
- W2081067748 cites W2162625274 @default.
- W2081067748 cites W2168763500 @default.
- W2081067748 cites W2171789898 @default.
- W2081067748 doi "https://doi.org/10.1002/j.1552-4604.1988.tb03150.x" @default.
- W2081067748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3392229" @default.
- W2081067748 hasPublicationYear "1988" @default.
- W2081067748 type Work @default.
- W2081067748 sameAs 2081067748 @default.
- W2081067748 citedByCount "14" @default.
- W2081067748 countsByYear W20810677482017 @default.
- W2081067748 countsByYear W20810677482019 @default.
- W2081067748 crossrefType "journal-article" @default.
- W2081067748 hasAuthorship W2081067748A5002022325 @default.
- W2081067748 hasAuthorship W2081067748A5019828694 @default.
- W2081067748 hasAuthorship W2081067748A5021075276 @default.
- W2081067748 hasAuthorship W2081067748A5030687612 @default.
- W2081067748 hasConcept C126322002 @default.
- W2081067748 hasConcept C178790620 @default.
- W2081067748 hasConcept C185592680 @default.
- W2081067748 hasConcept C2776414672 @default.
- W2081067748 hasConcept C2777022698 @default.
- W2081067748 hasConcept C2778162923 @default.
- W2081067748 hasConcept C2778994108 @default.
- W2081067748 hasConcept C2780035454 @default.
- W2081067748 hasConcept C2780149897 @default.
- W2081067748 hasConcept C2780356492 @default.
- W2081067748 hasConcept C2781328992 @default.
- W2081067748 hasConcept C29730261 @default.
- W2081067748 hasConcept C42219234 @default.
- W2081067748 hasConcept C50952357 @default.
- W2081067748 hasConcept C519063684 @default.
- W2081067748 hasConcept C537181965 @default.
- W2081067748 hasConcept C71924100 @default.
- W2081067748 hasConcept C85520022 @default.
- W2081067748 hasConcept C98274493 @default.
- W2081067748 hasConceptScore W2081067748C126322002 @default.
- W2081067748 hasConceptScore W2081067748C178790620 @default.
- W2081067748 hasConceptScore W2081067748C185592680 @default.
- W2081067748 hasConceptScore W2081067748C2776414672 @default.
- W2081067748 hasConceptScore W2081067748C2777022698 @default.
- W2081067748 hasConceptScore W2081067748C2778162923 @default.
- W2081067748 hasConceptScore W2081067748C2778994108 @default.
- W2081067748 hasConceptScore W2081067748C2780035454 @default.
- W2081067748 hasConceptScore W2081067748C2780149897 @default.
- W2081067748 hasConceptScore W2081067748C2780356492 @default.
- W2081067748 hasConceptScore W2081067748C2781328992 @default.
- W2081067748 hasConceptScore W2081067748C29730261 @default.
- W2081067748 hasConceptScore W2081067748C42219234 @default.
- W2081067748 hasConceptScore W2081067748C50952357 @default.
- W2081067748 hasConceptScore W2081067748C519063684 @default.
- W2081067748 hasConceptScore W2081067748C537181965 @default.
- W2081067748 hasConceptScore W2081067748C71924100 @default.
- W2081067748 hasConceptScore W2081067748C85520022 @default.
- W2081067748 hasConceptScore W2081067748C98274493 @default.
- W2081067748 hasIssue "4" @default.
- W2081067748 hasLocation W20810677481 @default.
- W2081067748 hasLocation W20810677482 @default.
- W2081067748 hasOpenAccess W2081067748 @default.
- W2081067748 hasPrimaryLocation W20810677481 @default.
- W2081067748 hasRelatedWork W1991102639 @default.
- W2081067748 hasRelatedWork W2043001651 @default.
- W2081067748 hasRelatedWork W2046580330 @default.
- W2081067748 hasRelatedWork W2081067748 @default.
- W2081067748 hasRelatedWork W2081377845 @default.
- W2081067748 hasRelatedWork W2138811304 @default.
- W2081067748 hasRelatedWork W2334890366 @default.
- W2081067748 hasRelatedWork W2355581162 @default.
- W2081067748 hasRelatedWork W2360323583 @default.
- W2081067748 hasRelatedWork W2421496487 @default.
- W2081067748 hasVolume "28" @default.
- W2081067748 isParatext "false" @default.
- W2081067748 isRetracted "false" @default.
- W2081067748 magId "2081067748" @default.
- W2081067748 workType "article" @default.