FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081076484> ?p ?o ?g. }

• W2081076484 abstract "To clarify the mechanisms of O2- formation by polymorphonuclear leukocytes (PMNs), the effects of clinically employed drugs on PMNs were investigated by measuring changes in membrane potential and rates of O2- production. These variables were effectively diminished with antihistaminic agents, adrenergic beta-antagonists, and antiarrhythmic drugs when guinea pig peritoneal PMNs were stimulated by either phorbol myristate acetate (PMA) or n-formyl-methionyl-leucyl-phenylalanine (FMLP). The order of potency of the inhibitory effects of these chemicals on the PMA-induced O2- formation was as follows: azelastine (IC50 = 4.1 microM) less than clemastine less than dl-propranolol less than chlorpheniramine maleate less than dichlorisoproterenol less than quinidine less than diphenhydramine less than indomethacin (IC50 greater than 400 microM). Similar phenomena were observed when FMLP was employed instead of PMA, but the FMLP-stimulated O2- production was effectively inhibited by indomethacin. Changes in membrane potential, using the cyanin dye method, also indicated that most of these drugs cancelled functional changes of plasma membrane of PMNs. From these observations, it was demonstrated that changes in membrane potential by the stimuli were essential for the initiation of O2- generation from plasma membrane of PMNs, although the initiation mechanisms were not identical for the two stimuli." @default.
• W2081076484 created "2016-06-24" @default.
• W2081076484 creator A5021463849 @default.
• W2081076484 creator A5068423688 @default.
• W2081076484 date "1984-10-01" @default.
• W2081076484 modified "2023-09-24" @default.
• W2081076484 title "Inhibitory effects of various drugs on phorbol myristate acetate and n−-formyl methionyl leucyl phenylalanine induced O2− production in polymorphonuclear leukocytes" @default.
• W2081076484 cites W133190639 @default.
• W2081076484 cites W1599532890 @default.
• W2081076484 cites W1900423039 @default.
• W2081076484 cites W1964949188 @default.
• W2081076484 cites W1969303674 @default.
• W2081076484 cites W1969823173 @default.
• W2081076484 cites W1970609137 @default.
• W2081076484 cites W1971898129 @default.
• W2081076484 cites W1971988464 @default.
• W2081076484 cites W1985890287 @default.
• W2081076484 cites W1987677045 @default.
• W2081076484 cites W2000991354 @default.
• W2081076484 cites W2001019186 @default.
• W2081076484 cites W2001688052 @default.
• W2081076484 cites W2007710990 @default.
• W2081076484 cites W2017904446 @default.
• W2081076484 cites W2019933973 @default.
• W2081076484 cites W2019946790 @default.
• W2081076484 cites W2020335253 @default.
• W2081076484 cites W2027347410 @default.
• W2081076484 cites W2041195097 @default.
• W2081076484 cites W2047501562 @default.
• W2081076484 cites W2082547425 @default.
• W2081076484 cites W2091363425 @default.
• W2081076484 cites W2093121239 @default.
• W2081076484 cites W2095658318 @default.
• W2081076484 cites W2117966002 @default.
• W2081076484 cites W2146800979 @default.
• W2081076484 cites W2170925294 @default.
• W2081076484 cites W2174934515 @default.
• W2081076484 cites W2402368012 @default.
• W2081076484 doi "https://doi.org/10.1016/0006-2952(84)90072-8" @default.
• W2081076484 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6148947" @default.
• W2081076484 hasPublicationYear "1984" @default.
• W2081076484 type Work @default.
• W2081076484 sameAs 2081076484 @default.
• W2081076484 citedByCount "39" @default.
• W2081076484 crossrefType "journal-article" @default.
• W2081076484 hasAuthorship W2081076484A5021463849 @default.
• W2081076484 hasAuthorship W2081076484A5068423688 @default.
• W2081076484 hasConcept C134018914 @default.
• W2081076484 hasConcept C17077164 @default.
• W2081076484 hasConcept C181199279 @default.
• W2081076484 hasConcept C185592680 @default.
• W2081076484 hasConcept C195794163 @default.
• W2081076484 hasConcept C198677920 @default.
• W2081076484 hasConcept C202751555 @default.
• W2081076484 hasConcept C203014093 @default.
• W2081076484 hasConcept C2777431362 @default.
• W2081076484 hasConcept C2777983669 @default.
• W2081076484 hasConcept C2778151854 @default.
• W2081076484 hasConcept C2778815084 @default.
• W2081076484 hasConcept C2780043322 @default.
• W2081076484 hasConcept C2780339425 @default.
• W2081076484 hasConcept C2780656570 @default.
• W2081076484 hasConcept C515207424 @default.
• W2081076484 hasConcept C55493867 @default.
• W2081076484 hasConcept C57992300 @default.
• W2081076484 hasConcept C86803240 @default.
• W2081076484 hasConcept C98274493 @default.
• W2081076484 hasConceptScore W2081076484C134018914 @default.
• W2081076484 hasConceptScore W2081076484C17077164 @default.
• W2081076484 hasConceptScore W2081076484C181199279 @default.
• W2081076484 hasConceptScore W2081076484C185592680 @default.
• W2081076484 hasConceptScore W2081076484C195794163 @default.
• W2081076484 hasConceptScore W2081076484C198677920 @default.
• W2081076484 hasConceptScore W2081076484C202751555 @default.
• W2081076484 hasConceptScore W2081076484C203014093 @default.
• W2081076484 hasConceptScore W2081076484C2777431362 @default.
• W2081076484 hasConceptScore W2081076484C2777983669 @default.
• W2081076484 hasConceptScore W2081076484C2778151854 @default.
• W2081076484 hasConceptScore W2081076484C2778815084 @default.
• W2081076484 hasConceptScore W2081076484C2780043322 @default.
• W2081076484 hasConceptScore W2081076484C2780339425 @default.
• W2081076484 hasConceptScore W2081076484C2780656570 @default.
• W2081076484 hasConceptScore W2081076484C515207424 @default.
• W2081076484 hasConceptScore W2081076484C55493867 @default.
• W2081076484 hasConceptScore W2081076484C57992300 @default.
• W2081076484 hasConceptScore W2081076484C86803240 @default.
• W2081076484 hasConceptScore W2081076484C98274493 @default.
• W2081076484 hasLocation W20810764841 @default.
• W2081076484 hasLocation W20810764842 @default.
• W2081076484 hasOpenAccess W2081076484 @default.
• W2081076484 hasPrimaryLocation W20810764841 @default.
• W2081076484 hasRelatedWork W2013332323 @default.
• W2081076484 hasRelatedWork W2017834203 @default.
• W2081076484 hasRelatedWork W2071651328 @default.
• W2081076484 hasRelatedWork W2081076484 @default.
• W2081076484 hasRelatedWork W2119502045 @default.
• W2081076484 hasRelatedWork W2396355134 @default.
• W2081076484 hasRelatedWork W2493153392 @default.
• W2081076484 hasRelatedWork W2987368790 @default.
• W2081076484 hasRelatedWork W2993433817 @default.

• next