Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081087560> ?p ?o ?g. }
- W2081087560 endingPage "658" @default.
- W2081087560 startingPage "649" @default.
- W2081087560 abstract "Epidermal growth factor receptor (EGFR) and its family members, ErbB2, ErbB3 and ErbB4, are receptor tyrosine kinases which send signals into the cell to regulate many critical processes including development, tissue homeostasis, and tumorigenesis. Central to the signaling of these receptors is their intracellular kinase domain, which is activated by ligand-induced dimerization of the receptor and phosphorylates several tyrosine residues in the C-terminal tail. The phosphorylated tail then recruits other signaling molecules and relays the signal to downstream pathways. A model of the autoinhibition, activation and feedback inhibition mechanisms for the ErbB kinase domain has emerged from a number of recent structural studies. Meanwhile, recent clinical studies have revealed the relationship between specific ErbB kinase mutations and the responsiveness to kinase inhibitor drugs. We will review these regulation mechanisms of the ErbB kinase domain, and discuss the binding specificity of kinase inhibitors and the effects of kinase domain mutations found in cancer patients from a structural perspective." @default.
- W2081087560 created "2016-06-24" @default.
- W2081087560 creator A5001373717 @default.
- W2081087560 creator A5082774427 @default.
- W2081087560 date "2009-02-01" @default.
- W2081087560 modified "2023-10-11" @default.
- W2081087560 title "The ErbB kinase domain: Structural perspectives into kinase activation and inhibition" @default.
- W2081087560 cites W1524333424 @default.
- W2081087560 cites W1555536872 @default.
- W2081087560 cites W1578456230 @default.
- W2081087560 cites W1597274086 @default.
- W2081087560 cites W1606458257 @default.
- W2081087560 cites W1870193477 @default.
- W2081087560 cites W1964321121 @default.
- W2081087560 cites W1966658428 @default.
- W2081087560 cites W1967758178 @default.
- W2081087560 cites W1974251191 @default.
- W2081087560 cites W1977926787 @default.
- W2081087560 cites W1978329718 @default.
- W2081087560 cites W1984852348 @default.
- W2081087560 cites W1992945955 @default.
- W2081087560 cites W1995675538 @default.
- W2081087560 cites W2002937040 @default.
- W2081087560 cites W2012347372 @default.
- W2081087560 cites W2012634952 @default.
- W2081087560 cites W2015927571 @default.
- W2081087560 cites W2020833679 @default.
- W2081087560 cites W2021538232 @default.
- W2081087560 cites W2022356570 @default.
- W2081087560 cites W2022847745 @default.
- W2081087560 cites W2024651005 @default.
- W2081087560 cites W2029011992 @default.
- W2081087560 cites W2033869679 @default.
- W2081087560 cites W2035024352 @default.
- W2081087560 cites W2036740994 @default.
- W2081087560 cites W2037873277 @default.
- W2081087560 cites W2038742557 @default.
- W2081087560 cites W2039705701 @default.
- W2081087560 cites W2040194285 @default.
- W2081087560 cites W2040912449 @default.
- W2081087560 cites W2042378775 @default.
- W2081087560 cites W2042816516 @default.
- W2081087560 cites W2043696829 @default.
- W2081087560 cites W2045156702 @default.
- W2081087560 cites W2045709340 @default.
- W2081087560 cites W2046151919 @default.
- W2081087560 cites W2049184213 @default.
- W2081087560 cites W2052221882 @default.
- W2081087560 cites W2058620780 @default.
- W2081087560 cites W2060671481 @default.
- W2081087560 cites W2062706311 @default.
- W2081087560 cites W2070170550 @default.
- W2081087560 cites W2079596997 @default.
- W2081087560 cites W2082592896 @default.
- W2081087560 cites W2086020303 @default.
- W2081087560 cites W2088806906 @default.
- W2081087560 cites W2092897704 @default.
- W2081087560 cites W2094654898 @default.
- W2081087560 cites W2095381863 @default.
- W2081087560 cites W2096061368 @default.
- W2081087560 cites W2097097666 @default.
- W2081087560 cites W2100794900 @default.
- W2081087560 cites W2106186049 @default.
- W2081087560 cites W2111109297 @default.
- W2081087560 cites W2128307445 @default.
- W2081087560 cites W2131174104 @default.
- W2081087560 cites W2132334410 @default.
- W2081087560 cites W2132448632 @default.
- W2081087560 cites W2133051701 @default.
- W2081087560 cites W2133185088 @default.
- W2081087560 cites W2133867160 @default.
- W2081087560 cites W2139236349 @default.
- W2081087560 cites W2140614532 @default.
- W2081087560 cites W2143600397 @default.
- W2081087560 cites W2145497412 @default.
- W2081087560 cites W2156480395 @default.
- W2081087560 cites W2156842451 @default.
- W2081087560 cites W2159013299 @default.
- W2081087560 cites W2161821474 @default.
- W2081087560 cites W2165926532 @default.
- W2081087560 cites W2166237363 @default.
- W2081087560 cites W2169816570 @default.
- W2081087560 cites W2170629989 @default.
- W2081087560 doi "https://doi.org/10.1016/j.yexcr.2008.07.031" @default.
- W2081087560 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2668223" @default.
- W2081087560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18761339" @default.
- W2081087560 hasPublicationYear "2009" @default.
- W2081087560 type Work @default.
- W2081087560 sameAs 2081087560 @default.
- W2081087560 citedByCount "65" @default.
- W2081087560 countsByYear W20810875602012 @default.
- W2081087560 countsByYear W20810875602013 @default.
- W2081087560 countsByYear W20810875602014 @default.
- W2081087560 countsByYear W20810875602015 @default.
- W2081087560 countsByYear W20810875602016 @default.
- W2081087560 countsByYear W20810875602017 @default.
- W2081087560 countsByYear W20810875602018 @default.
- W2081087560 countsByYear W20810875602019 @default.