FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081101433> ?p ?o ?g. }

• W2081101433 endingPage "14" @default.
• W2081101433 startingPage "1" @default.
• W2081101433 abstract "Thiazolidinediones (TZDs) are synthetic ligands of Peroxisome-Proliferator-Activated Receptor gamma (PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>γ</mml:mi></mml:mrow></mml:math>). Troglitazone, rosiglitazone, and pioglitazone have been approved for treatment of diabetes mellitus type II. All three compounds, together with the first TZD ciglitazone, also showed an antitumor effect in preclinical studies and a beneficial effect in some clinical trials. This review summarizes hypotheses on the role of PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mi>γ</mml:mi></mml:mrow></mml:math>in tumors, on cellular targets of TZDs, antitumor effects of monotherapy and of TZDs in combination with other compounds, with a focus on their role in the treatment of differentiated thyroid carcinoma. The results of chemopreventive effects of TZDs are also considered. Existing data suggest that the action of TZDs is highly complex and that actions do not correlate with cellular PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mi>γ</mml:mi></mml:mrow></mml:math>expression status. Effects are cell-, species-, and compound-specific and concentration-dependent. Data from human trials suggest the efficacy of TZDs as monotherapy in prostate cancer and glioma and as chemopreventive agent in colon, lung, and breast cancer. TZDs in combination with other therapies might increase antitumor effects in thyroid cancer, soft tissue sarcoma, and melanoma." @default.
• W2081101433 created "2016-06-24" @default.
• W2081101433 creator A5024722162 @default.
• W2081101433 creator A5038414635 @default.
• W2081101433 date "2015-01-01" @default.
• W2081101433 modified "2023-10-16" @default.
• W2081101433 title "Chemotherapy and Chemoprevention by Thiazolidinediones" @default.
• W2081101433 cites W1122404497 @default.
• W2081101433 cites W1511151098 @default.
• W2081101433 cites W1532932203 @default.
• W2081101433 cites W1844018813 @default.
• W2081101433 cites W1879008530 @default.
• W2081101433 cites W1954381882 @default.
• W2081101433 cites W1963663550 @default.
• W2081101433 cites W1963900745 @default.
• W2081101433 cites W1966598111 @default.
• W2081101433 cites W1968980738 @default.
• W2081101433 cites W1970020544 @default.
• W2081101433 cites W1972499055 @default.
• W2081101433 cites W1973809884 @default.
• W2081101433 cites W1975160900 @default.
• W2081101433 cites W1980226777 @default.
• W2081101433 cites W1983538557 @default.
• W2081101433 cites W1984962799 @default.
• W2081101433 cites W1988862769 @default.
• W2081101433 cites W1992365965 @default.
• W2081101433 cites W1992610206 @default.
• W2081101433 cites W1994271773 @default.
• W2081101433 cites W1998348781 @default.
• W2081101433 cites W1998440406 @default.
• W2081101433 cites W1999063912 @default.
• W2081101433 cites W2001480066 @default.
• W2081101433 cites W2001676296 @default.
• W2081101433 cites W2002762124 @default.
• W2081101433 cites W2002880821 @default.
• W2081101433 cites W2003699768 @default.
• W2081101433 cites W2005159659 @default.
• W2081101433 cites W2006801827 @default.
• W2081101433 cites W2008139865 @default.
• W2081101433 cites W2010085580 @default.
• W2081101433 cites W2013679434 @default.
• W2081101433 cites W2017018123 @default.
• W2081101433 cites W2019607817 @default.
• W2081101433 cites W2021809025 @default.
• W2081101433 cites W2023108227 @default.
• W2081101433 cites W2023186997 @default.
• W2081101433 cites W2024761791 @default.
• W2081101433 cites W2029212596 @default.
• W2081101433 cites W2029501542 @default.
• W2081101433 cites W2029587810 @default.
• W2081101433 cites W2029599625 @default.
• W2081101433 cites W2030414680 @default.
• W2081101433 cites W2030808013 @default.
• W2081101433 cites W2032312933 @default.
• W2081101433 cites W2034074585 @default.
• W2081101433 cites W2035539313 @default.
• W2081101433 cites W2036145275 @default.
• W2081101433 cites W2037395185 @default.
• W2081101433 cites W2037665781 @default.
• W2081101433 cites W2038781914 @default.
• W2081101433 cites W2040642592 @default.
• W2081101433 cites W2040920295 @default.
• W2081101433 cites W2041327710 @default.
• W2081101433 cites W2041672953 @default.
• W2081101433 cites W2041814600 @default.
• W2081101433 cites W2041993106 @default.
• W2081101433 cites W2043297579 @default.
• W2081101433 cites W2043488498 @default.
• W2081101433 cites W2045833013 @default.
• W2081101433 cites W2048769469 @default.
• W2081101433 cites W2050352100 @default.
• W2081101433 cites W2052052955 @default.
• W2081101433 cites W2052680744 @default.
• W2081101433 cites W2053259702 @default.
• W2081101433 cites W2054514792 @default.
• W2081101433 cites W2055051324 @default.
• W2081101433 cites W2055561557 @default.
• W2081101433 cites W2055642631 @default.
• W2081101433 cites W2056734036 @default.
• W2081101433 cites W2057041212 @default.
• W2081101433 cites W2058035682 @default.
• W2081101433 cites W2058418464 @default.
• W2081101433 cites W2060337173 @default.
• W2081101433 cites W2060497505 @default.
• W2081101433 cites W2061617742 @default.
• W2081101433 cites W2063031174 @default.
• W2081101433 cites W2063064231 @default.
• W2081101433 cites W2063647384 @default.
• W2081101433 cites W2064669831 @default.
• W2081101433 cites W2066119785 @default.
• W2081101433 cites W2067084032 @default.
• W2081101433 cites W2068559608 @default.
• W2081101433 cites W2068753267 @default.
• W2081101433 cites W2068754312 @default.
• W2081101433 cites W2069436212 @default.
• W2081101433 cites W2070723208 @default.
• W2081101433 cites W2071145042 @default.
• W2081101433 cites W2072249486 @default.

• next